フルテキストファイル
著者
Sakurai Yuko Division of Child Neurology, Institute of Neurological Sciences, Tottori University Faculty of Medicine
Saito Yoshiaki Department of Child Neurology, National Center Hospital of Neurology and Psychiatry 研究者総覧 KAKEN
Nanba Eiji Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University 研究者総覧 KAKEN
Yamamoto Toshiyuki International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women’s Medical University
Ohno Kousaku Division of Child Neurology, Institute of Neurological Sciences, Tottori University Faculty of Medicine KAKEN
キーワード
colorectal neoplasm
gene analysis
matrix metalloproteinase
polymorphism
tumor necrosis factor-alpha
抄録
Colorectal carcinogenesis involves environmental factors and genetic predispositions. Recent studies have suggested the associations between colorectal neoplasm and functional polymorphism of matrix metalloproteinases (MMPs) and cytokine genes. In this study, we analyzed polymorphisms of MMPs and tumor necrosis factor (TNF)-alpha genes, focusing on the susceptibility to colorectal neoplasm and the tumor progression. The subjects were 186 patients (95 men and 91 women) who underwent total colonoscopy, and were classified into cancer, adenoma and non-neoplasm (control) groups of 47, 72 and 67 patients, respectively. The polymorphisms at the MMP-2 ?1306C/T, MMP-3 ?1171 5A/6A, MMP-7 ?181A/G, MMP-9 ?1562C/T and TNF-alpha ?308G/A loci were analyzed. Regarding background factors, significant differences were found in the age, sex ratio and alcohol-drinking and cigarette-smoking histories in the adenoma and cancer groups, compared to those in the control group. On these factors-adjusted logistic regression analysis of polymorphisms and disease susceptibility, no significant difference was noted in the frequency of any polymorphism in the adenoma and cancer groups, compared to those in the control group. The analysis of the involvement of polymorphisms in tumor progression in the adenoma and cancer groups revealed that the odds ratio for the MMP-3 5A allele was significantly higher in the cancer group (2.74; 95% confidence interval = 1.11?6.74, P = 0.02). The polymorphisms of MMP genes and TNF-alpha genes were not associated with the susceptibility to colorectal neoplasm, but the involvement of the MMP-3 5A allele in the progression of adenoma to cancer was suggested.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
52
1
開始ページ
57
終了ページ
72
発行日
2009-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2009, 52(1), 57-72
部局名
医学部・医学系研究科・医学部附属病院
言語
英語