フルテキストファイル
著者
Nakagome Kazuyuki Division of Neuropsychiatry, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
Ikezawa Satoru Division of Neuropsychiatry, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine
Pu Sheng Hong Division of Neuropsychiatry, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
キーワード
cognitive function
functional outcome
mismatch negativity
N-methyl-D-aspartate
schizophrenia
抄録
It is now widely accepted that cognitive deficits, beyond other psychiatric symptoms (e.g., delusion, hallucination, emotional flattening, social withdrawal and apathy), is far most relevant to social functional outcome in schizophrenia. Accordingly, the treatment target has been shifted to the area, developing new drugs that facilitate cognitive function and building up new psychosocial rehabilitation programs that directly approach the cognitive deficits. Despite the desirability to target these deficits, no standard neuropsychological test batteries exist for assessing the level of cognitive function. Mismatch negativity (MMN), an auditory event-related potential component, is a measure of preattentive information processing and its amplitude has repeatedly been demonstrated to be reduced in schizophrenia. MMN deficits are a robust feature in chronic schizophrenia and indicate abnormalities in automatic context-dependent auditory information processing and auditory sensory memory in schizophrenia. Moreover, the deficits have been related to poor social functioning level and social skills acquisition, hypofunction of NMDA system, and illness duration, which indicate the validity of accepting MMN as a biomarker of the disease. In this article, we present a summary of the discussions about the plausibility of MMN to be used as a neurobiological index for assessing the cognitive function and also its predictability of social functional outcome in schizophrenia.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
50
2
開始ページ
23
終了ページ
32
発行日
2007-06
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2007, 50(2), 23-32
部局名
医学部・医学系研究科・医学部附属病院
言語
英語