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著者
Kuwamoto Masaru Division of Orthopaedic Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine
Okano Toru Division of Orthopaedic Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine
Fukata Satoru Division of Orthopaedic Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine
Enokida Makoto Division of Orthopaedic Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Hagino Hiroshi Division of Orthopaedic Surgery, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine 研究者総覧 KAKEN
キーワード
bone mineral density
collagen-induced arthritis
peripheral quantitative computed tomography
rheumatoid arthritis
sciatic neurectomy
抄録
We investigated the effects of sciatic neurectomy on arthritis and bone mineral density (BMD) in 7-month-old female Sprague-Dawley rats with collagen-induced arthritis (CIA). After the animals obtained a uniform mean body weight, we divided them at random into 4 groups, and treated them with the following surgical manipulations: (i) sham group (n = 8), sham surgery; (ii) CIA group (n = 9), collagen sensitization and sham surgery; (iii) NTx group (n = 9), sciatic neurectomy and (iv) CIA + NTx group (n = 9), collagen sensitization and a sciatic neurectomy. Every 2 weeks up to 8 weeks after sensitization, the arthritis score for hind paw swelling was evaluated, and BMD of the cancellous and cortical bones in the proximal tibia was measured by peripheral quantitative computed tomography (pQCT). Both the hind paw swelling and arthritis score in the CIA + NTx group were significantly lower than those in the CIA group at 6 and 8 weeks after sensitization. There was no significant difference in the cancellous BMD between the CIA and CIA + NTx groups. The cortical BMD of the tibial metaphysis was significantly lower in the NTx and CIA + NTx groups than in the sham group at 4 and 8 weeks, and in the CIA + NTx group than in the CIA group at 4 weeks after sensitization. There was no significant difference between the CIA and sham groups as well as the CIA and CIA + NTx group at 8 weeks after sensitization. It was concluded that sciatic neurectomy suppressed the severity of arthritis, but did not affect the cancellous bone loss in adult CIA rats.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
50
3
開始ページ
57
終了ページ
63
発行日
2007-09
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2007, 50(3), 57-63
部局名
医学部・医学系研究科・医学部附属病院
言語
英語