フルテキストファイル
著者
Ataka Masayuki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Ikeguchi Masahide Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine KAKEN
Yamamoto Manabu Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine 研究者総覧
Inoue Masashi Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Tanida Takashi Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Oka Shin-ichi Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Katano Kuniyuki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
キーワード
colorectal cancer
DNA topoisomerase I
immunohistochemistry
prognosis
抄録
Topoisomerase I (Topo I) is known as a target for chemotherapy in advanced or recurrent colorectal cancer. In order to prolong the survival of patients with colorectal cancer or to prevent ineffective chemotherapy, we evaluated clinicopathological characteristics of Topo I protein in colorectal cancer. Also, we estimated whether Topo I protein expression of primary tumors could be a parameter for chemosensitivity of Topo I inhibitor in patients with cancer recurrence. Immunohistochemical detection of Topo I protein was performed in 104 surgically obtained specimens. Topo I protein was detected in 45 of 104 patients (43.2%). Topo I protein expression closely correlated with tumor progression, histpathological differentiation and poor prognosis of patients. Sixteen patients with recurrent cancer had been treated with Topo I inhibitor. Topo I inhibitor significantly prolonged the survival of 12 patients who had Topo I-positive primary tumors. Topo I protein expression in colorectal cancer may be a biological marker for chemosensitivity of tumors against Topo I inhibitors.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
50
4
開始ページ
81
終了ページ
87
発行日
2007-12
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2007, 50(4), 81-87
部局名
医学部・医学系研究科・医学部附属病院
言語
英語