フルテキストファイル
著者
Yamaguchi Hiroshi Department of Urology, Faculty of Medicine, Tottori University
キーワード
estradiol
major pelvic ganglia
ovariectomy
puberty
抄録
To elucidate the effect of estradiol (E2) on the morphology of the neurons of the lower urinary tract during puberty, we carried out morphometric and immunohistochemical analyses of the major pelvic ganglia (MPG) in female rats. Four-week-old female Wistar rats were divided into the following groups: normal controls, ovariectomies, and ovariectomies receiving E2 replacement. At the age of 12 weeks the MPG were stained with hematoxylin and eosin (H&E), and immunostained by the antibody against rat tyrosine hydroxylase (TH). Each section was evaluated by an image analysis system. In the ovariectomized rats, the size of neurons in the MPG was significantly reduced. Immunohistochemical analysis revealed that the size of TH-positive neurons was significantly increased compared with TH-negative neurons in the E2-replaced rats. The results suggest that pubertal estrogen deficit reduces the size of neurons in the MPG and that estrogen replacement increases neuron size, especially the adrenergic neurons in the MPG.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
41
1
開始ページ
17
終了ページ
22
発行日
1998-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 1998, 41(1), 17-22
部局名
医学部・医学系研究科・医学部附属病院
言語
英語