フルテキストファイル
著者
Shimamoto Kenji Department of Urology, Faculty of Medicine, Tottori University
Sofikitis Nikolaos Department of Urology, Faculty of Medicine, Tottori University
キーワード
cholesterol
infertility
sperm
temperature
testis
抄録
The effect of hypercholesterolaemia on testicular endocrine and exocrine function was evaluated. Furthermore, the influence of hypercholesterolaemia on sperm quality, quantity, and fertilizing potential was appreciated. Eight mature rabbits (group A) were fed chow containing 3% cholesterol for 12 weeks. An additional six rabbits (group B) were fed normal chow for the same period. At the end of the experimental period hormonal profiles and sperm parameters were evaluated. In addition, the sperm reproductive potential was assessed by in vitro fertilization (IVF) procedures. Peripheral serum responses to testicular stimulation with human chorionic gonadotropin, epididymal sperm content and motility, and IVF outcome were significantly lower in group A than in group B. In contrast, serum cholesterol levels were significantly higher in group A. It appears that hypercholesterolaemia has a detrimental effect on Leydig cell function, spermatogenesis, the epididymal sperm maturation process, and the overall sperm fertilizing capacity.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
41
1
開始ページ
23
終了ページ
29
発行日
1998-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 1998, 41(1), 23-29
部局名
医学部・医学系研究科・医学部附属病院
言語
英語