フルテキストファイル | |
著者 |
Satoh Yukio
Department of Biosignaling, Faculty of Medicine, Tottori University
Sairenji Takeshi
Department of Biosignaling, Faculty of Medicine, Tottori University
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キーワード | EGF receptor
EGF receptor mRNA
mRNA stability
regulation of gene expression
thyroid hormone
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抄録 | The expression of epidermal growth factor (EGF) receptor mRNA was examined using thyroid hormone L-3,5,3'-triiodothyronine (T3) by Northern blot analysis in rat hepatoma cells. The expression of full-length, but not truncated receptor mRNA was enhanced and destabilized with T3. These results suggest that T3 induces not only the expression of full-length EGF receptor mRNA but also accelerates their rate of turnover. The 3' terminal region of full-length EGF receptor mRNA may have a role in the destabilization of EGF receptor mRNA by T3, because truncated EGF receptor mRNA lacks only the 3' terminal region of full-length EGF receptor mRNA.
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出版者 | Tottori University Faculty of Medicine
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資料タイプ |
学術雑誌論文
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ISSN | 1346-8049
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書誌ID | AA00892882
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掲載誌名 | Yonago Acta medica
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最新掲載誌名 |
Yonago Acta medica
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巻 | 40
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号 | 3
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開始ページ | 133
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終了ページ | 136
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発行日 | 1997-11
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著者版フラグ |
出版社版
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著作権表記 | Yonago Acta medica 編集委員会
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掲載情報 | Yonago Acta medica. 1997, 40(3), 133-136
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部局名 |
医学部・医学系研究科・医学部附属病院
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言語 |
英語
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