フルテキストファイル
著者
Takemoto Hiroki Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
Makino Masato Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine
キーワード
colorectum
double primary cancer
mismatch repair deficiency
stomach
抄録
We examined the correlation between the expression of mismatch repair (MMR) gene proteins and the development of double primary cancer, and studied clinical implications of an MMR deficiency in 15 patients with double primary cancer of the colorectum and stomach, immunohistochemically. The results were compared between the double primary cancer group of 15 patients and the control group consisting of 155 colorectal cancer (CRC) patients who had never developed other malignant diseases. Patients with hereditary nonpolyposis colorectal cancer and familial adenomatous polyiposis were excluded from both groups. The MMR deficiency in CRC was significantly more frequently detected in the double primary cancer group than in the control group (46.7% versus 20.6%, P < 0.05). Patients with MMR-deficient CRC of the double primary cancer group were significantly older, more frequently had poorly differentiated lesions, had less metastases to the liver and lymph node, and were more advanced in depth of invasion than those of the control group. We concluded that MMR deficiency might correlate with the development of double primary cancer of the colorectum and stomach. Patients with MMR-deficient CRC need periodical and intensive follow-up against the development of double primary cancer.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
46
4
開始ページ
117
終了ページ
124
発行日
2003-12
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2003, 46(4), 117-124
部局名
医学部・医学系研究科・医学部附属病院
言語
英語