フルテキストファイル
著者
Suzuki Nobuo Department of Urology, Faculty of Medicine, Tottori University
Sofikitis Nikolaos Department of Urology, Faculty of Medicine, Tottori University
キーワード
antioxidants
reactive oxygen species
sperm quantity and quality
varicocele
抄録
Left varicocele detrimentally affects spermatogenesis and the epididymal sperm maturation process bilaterally. We analyzed the effect of antioxidants on sperm production and quality in rats which were varicocelized. Non-varicocelized rats served as controls (group A). Left varicocele was done in 5 groups (B, C, D, E and F) of rats of the same age. Antioxidants taurine, catalase or superoxide dismutase were administered intraabdominally twice a week in groups C, D or E, respectively. Group F received taurine, catalase and superoxide dismutase. Groups A and B received a vehicle dose of saline equally. Eight weeks after varicocele induction bilateral epididymal caudal sperm content, motility and fertilizing ability were analyzed. All the parameters were significantly lower in group B than in groups A, C, D, E and F, although the values in group A were higher than in the other groups. Bilateral testicular weight and testosterone responses to human chorionic gonadotropin stimulation were significantly higher in groups A, C, D, E and F than in the group B. There were no significant differences in serum testosterone basal profiles among groups A, B, C, D, E and F. These results indicated the effectiveness of antioxidants for the preservation of testicular function and the epididymal sperm maturation process in varicocelized subjects.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
42
1
開始ページ
87
終了ページ
94
発行日
1999-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 1999, 42(1), 87-94
部局名
医学部・医学系研究科・医学部附属病院
言語
英語