フルテキストファイル
著者
Dirgahayu Paramasari Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine
Fukumoto Soji Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine 研究者総覧 KAKEN
Tademoto Sayuri Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine
Hirai Kazumitsu Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine KAKEN
キーワード
human monocytes
mitogen-activated protein kinase
Plasmodium falciparum
Spirometra erinaceieuropaei
tumor necrosis factor-α
抄録
We have reported that excretory/secretory (ES) products from Spirometra erinaceieuropaei plerocercoids suppress production and gene expression of tumor necrosis factor (TNF)-α in murine macrophages stimulated with lipopolysaccharide. The present study demonstrates that ES products suppress TNF-α, interleukin (IL)-1β and intercellular adhesion molecule (ICAM)-1 gene expression in human monocytic leukemia cell line THP-1 stimulated with Plasmodium falciparum-cultured medium (Pf-CM). Inhibition of extracellular-signal regulated protein kinase 1/2 (ERK1/2) with PD98059 reduced TNF-α, IL-1β and ICAM-1 gene expression; on the contrary inhibition of p38 mitogen-activated protein kinase (MAPK) with SB203580 increased the expression of these genes. These findings indicated that ERK1/2, but not p38 MAPK pathway is important for induction of TNF-α, IL-1β and ICAM-1 gene expression in Pf-CM stimulated THP-1 monocytes. ES products additionally suppress IL-1β, but not TNF-α and ICAM-1 gene expression in Pf-CM stimulated THP-1 cells treated with PD98059. We hypothesize that ES products may be useful in reducing falciparum malaria-induced inflammatory response and sequestration in the late stage of malarial diseases such as cerebral malaria.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
47
1
開始ページ
7
終了ページ
15
発行日
2004-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2004, 47(1), 7-15
部局名
医学部・医学系研究科・医学部附属病院
言語
英語