フルテキストファイル
著者
Yang Chun-Hui Department of Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine
Otsuka Makoto Department of Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine
Ohama Eisaku Department of Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine
キーワード
Alzheimer's disease
cerebral amyloid angiopathy
immunohistochemistry
perivascular plaque
senile plaque
抄録
Immunohistochemical study of perivascular plaques (PPs) in 7 patients with Alzheimer’s disease (AD) and 4 with cerebral amyloid angiopathy (CAA)(CAA with dementia in 3 patients and CAA with massive cerebral hemorrhage in 1 patient) demonstrated that PPs were also a common form of amyloid β (Aβ) deposits, like SPs and CAAs, in both AD and CAA, and that they had similar immunostaining characteristics to mature senile plaques (SPs), manifesting as always positive for both Aβ42 and Aβ40 but predominant for Aβ42. In addition, PPs were always associated with AT8-positive degenerated neurites and GFAP-positive astrocytes and fibers. These findings suggest that PPs as mature plaques contribute to the development of dementia, especially in CAA with dementia which lack AD pathology. Moreover, semiquantitative analysis revealed no correlation between the number of PPs and that of SPs, but a good correlation between the number of PPs and that of CAAs, suggesting that there was a close relationship of the formation of PPs and the development of CAAs. PPs were also found around non-CAA arteries, although they were frequent around varying degrees of CAAs, suggesting that the initial Aβ42 deposits in PPs contribute to the development of CAAs.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
46
1
開始ページ
9
終了ページ
16
発行日
2003-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2003, 46(1), 9-16
部局名
医学部・医学系研究科・医学部附属病院
言語
英語