フルテキストファイル
著者
Oota Shigeo First Department of Physiology, Faculty of Medicine, Tottori University
キーワード
electron microscopy
epidermis
Langerhans cells
methylene blue
抄録
In 1868, Langerhans discovered the dendritic cells now generally called Langerhans cells (LCs) in the human epidermis using the gold impregnation method. He pointed out that the terminals of the upward running processes of the cells end with button-like swellings under the cornified layer. In 1951, Ferreira-Marques classified the shapes of the terminals into 7 types, named the largest one Organum trompiforme and reckoned it to be a sense receptor. However, the swellings of the process terminals seem to have been entirely forgotten along with the negation of the nerve cell theory of LCs. The author of this study recovered some of the actual forgotten terminals, the button-shaped (knopff?rmig) swellings of the process terminals of the cells, beneath the cornified layer of a healthy volunteer epidermis using the methylene blue staining method. Furthermore, the ultrastructures of the swellings were captured for the first time using the Thin-Section-Reembedding and Ultrathin-Sectioning (TRUS) technique named by the author. Investigation of the swellings by electron microscopy showed that there were a number of Birbeck granules and vacuoles of various sizes together with elements of cytoskeletons in the cytoplasm. Possibly this shows that LCs play an essential role in the differentiation of the epidermis at the process terminals.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
42
2
開始ページ
153
終了ページ
161
発行日
1999-07
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 1999, 42(2), 153-161
部局名
医学部・医学系研究科・医学部附属病院
言語
英語