フルテキストファイル
著者
Miyazaki Akiko Department of Molecular Biology, and Second Department of Surgery, Tottori University Faculty of Medicine
Tsukamoto Yoshiyuki Department of Molecular Biology, Tottori University Faculty of Medicine
Sato Kenzo Department of Molecular Biology, Tottori University Faculty of Medicine KAKEN
Ohgi Shigetsugu Second Department of Surgery, Tottori University Faculty of Medicine KAKEN
Moriyama Masatsugu Department of Molecular Biology, Tottori University Faculty of Medicine
キーワード
Arpp
Carp
E box
heart
skeletal muscle
抄録
A novel ankyrin-repeated protein, Arpp, is specifically expressed in skeletal and cardiac muscles. Arpp protein is homologous, in its amino acid sequences (52.7% identity), to Carp protein which is proposed to be a putative genetic marker for cardiac hypertrophy. In this study, we isolated the human Arpp gene by screening a human genomic library and analyzed the genomic structure and its 5' flanking region. The Arpp gene was found to encompass a sequence of 11 kb and to consist of 9 exons. The translational initiation site and the stop codon were found to be located at exon 1 and exon 9, respectively. Each exon from 5 to 8 was found to encode 1 of the 4 ankyrin-like domains, respectively. The 2.7 kb upstream of exon 1 was sequenced. The TATA box was identified 29 bp upstream of the transcriptional start site, and multiple putative regulatory elements including the E box and upstream stimulating factor-1 were distributed within the proximal promoter regions. Since these elements were also found in the promoter region of the mouse Arpp gene, they may play an important role in the transcriptional regulation of both human and murine Arpp genes.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
45
1
開始ページ
1
終了ページ
8
発行日
2002-03
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2002, 45(1), 1-8
部局名
医学部・医学系研究科・医学部附属病院
言語
英語