フルテキストファイル
著者
Taniguchi Yuji Division of Organ Regeneration Surgery, Department of Surgery, School of Medicine, Tottori University
キーワード
cytokine
cytokine production per hour
hourly production of cytokine
lung cancer
vascular endothelial growth factor
wound healing
抄録
Some pro- and anti-inflammatory cytokines and angiogenesis-related factors play important roles in the inflammatory response after surgery. To study their kinetics and mutual relationships after major lung resection for lung cancer, concentrations of interleukin (IL)-6, -8 and -10 and vascular endothelial growth factor (VEGF) were measured in serum and pleural fluid. Venous blood and pleural fluid samples were collected before and up until 5 days after surgery from 10 patients with lung cancer, treated by standard lobectomy at Tottori University Hospital between 1997 and 1999. Cytokine levels after surgery were significantly higher than control levels before surgery in serum and pleural fluid. In pleural fluid, cytokines and VEGF increased after surgery 10 to 100 times than in serum. IL-6 and -10 reached their peaks in pleural fluid later than in serum, and then gradually decreased. Serum IL-8 reached its peak at 3 h, decreased until day 2 and then remained stable. Serum VEGF decreased until 3 h, and then showed little change. Pleural fluid IL-8 and VEGF reached their peaks at 3 or 6 h, decreased until day 2 and then increased up to day 5. The amount of cytokines produced per hour in drainage pleural fluid showed nearly the same kinetics as serum cytokines. Serum cytokines and VEGF showed higher coefficient values to the hourly production in pleural fluid than to the pleural fluid levels. During wound healing, IL-8 acted as a pro-inflammatory cytokine in the early phase, but as an angiogenic factor like VEGF in the late proliferative phase. The cytokine production per hour in pleural fluid is believed to be a useful marker of cytokine levels for evaluating surgical trauma after major lung resection for lung cancer.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
45
2
開始ページ
49
終了ページ
57
発行日
2002-06
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 2002, 45(2), 49-57
部局名
医学部・医学系研究科・医学部附属病院
言語
英語