| フルテキストファイル | |
| 著者 |
Kataoka Hideyuki
Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
研究者総覧
KAKEN
Nakano Seiji
Division of Molecular Genetics and Biofunction, Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University
Kunimoto Yasuomi
Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
研究者総覧
KAKEN
Sugie Naoko
Division of Molecular Genetics and Biofunction, Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University
Osaki Mitsuhiko
Division of Molecular Genetics and Biofunction, Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University
研究者総覧
KAKEN
Uzawa Narikazu
Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University
Yoshida Mitsuaki A.
Biodosimetry Section, Department of Radiation Dosimetry, Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences
Oshimura Mitsuo
Division of Molecular Genetics and Biofunction, Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University
KAKEN
Kitano Hiroya
Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine
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| キーワード | head and neck squamous cell carcinoma
loss of imprinting
PEG1/MEST
|
| 抄録 | Genomic imprinting is an epigenetic feature that plays a significant role in carcinogenesis. In this study, we examined the expression status of an imprinted gene, paternally expressed gene 1/mesoderm-specific transcript PEG1/MEST, in 38 cases of head and neck squamous cell carcinomas (HNSCCs) and in 17 oral squamous cancer cell lines. Loss of imprinting (LOI) of PEG1/MEST was found in 8 of 10 (80%) in tumor specimens, and 6 of 10 (60%) informative cases even in the extracted normal tissue specimens. As for the oral squamous cancer cell lines, LOI was detected in 5 of 8 (62.5%) informative cases in PEG1/MEST. Thus, these data showed that abnormal expression of PEG1/MEST was found at a high frequency in the tumor, the extracted normal tissue specimens and the oral squamous cancer cell lines. PEG1/MEST LOI in extracted normal tissue specimens may have a potential individual cancer risk for HNSCC.
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| 出版者 | Tottori University Faculty of Medicine
|
| 資料タイプ |
学術雑誌論文
|
| ISSN | 1346-8049
|
| 書誌ID | AA00892882
|
| 掲載誌名 | Yonago Acta medica
|
| 最新掲載誌名 |
Yonago Acta medica
|
| 巻 | 52
|
| 号 | 2
|
| 開始ページ | 85
|
| 終了ページ | 90
|
| 発行日 | 2009-06
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| 著者版フラグ |
出版社版
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| 著作権表記 | Yonago Acta medica 編集委員会
|
| 掲載情報 | Yonago Acta medica. 2009, 52(2), 85-90
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| 部局名 |
医学部・医学系研究科・医学部附属病院
|
| 言語 |
英語
|
