yam64(4)_339.pdf 1.12 MB
Tomita, Katsuki Department of Respiratory Medicine, National Hospital Organization Yonago Medical Center
Okada, Shinichi Department of Pediatrics, National Hospital Organization Yonago Medical Center 研究者総覧 KAKEN
Sugihara, Shuji Department of Radiology, National Hospital Organization Yonago Medical Center
Ikeuchi, Tomoyuki Department of Respiratory Medicine, National Hospital Organization Yonago Medical Center
Touge, Hirokazu Department of Respiratory Medicine, National Hospital Organization Yonago Medical Center
Hasegawa, Junnichi Department of Internal Medicine, National Hospital Organization Yonago Medical Center
Yamasaki, Akira Division of Medical Oncology and Molecular Respirology, School of Medicine, Faculty of Medicine, Tottori University 研究者総覧 KAKEN
Background: BNT162b2, an mRNA COVID-19 vaccine, was launched in many countries as an intramuscular vaccination for COVID-19 infection. Few studies have assessed the physical indications of pain at the immunization site. This study aimed to characterize pain at the injection site and investigate morphological attributes using ultrasound. Methods: Forty-three of 211 healthcare workers who received a second dose of BNT162b2 between February 2021 and March 2021 were enrolled in the study. The mean age of the subjects was 40 years. We evaluated patients’ pain at the injection site using the Numerical Rating Pain Scale (NRPS). We also assessed the thickness of the deltoid muscle fascia at the injection site by ultrasound. Bayesian robust correlation was employed to explore the relationship between the pain intensity scores and ultrasound measurements. Results: All eligible subjects complained of pain at the injection site. A median pain onset of 8 hours post-vaccination and a median peak intensity score of 4 were reported. Onset of relief occurred after 2 days. Ultrasound images demonstrated a 2.5-fold increase in fascia thickness at the injection site without intramuscular echogenicity change in all subjects. A correlation was established between the NRPS score and the non-injection-to-injection-side ratio of fascia thickness at the injection site (rho = 0.66). Conclusion: A sore arm was the most prevalent side effect of BNT162b2 vaccination and could be attributed to temporal fasciitis.
Tottori University Medical Press
Yonago Acta Medica
Yonago Acta Medica
(C) 2021 Tottori University Medical Press.
Tomita K, Okada S, Sugihara S, et al. Physical Characteristics of Injection Site Pain After COVID-19 mRNA BNT162b2 Vaccination. Yonago Acta Medica. 2021, 64(4), 339-344. doi:10.33160/yam.2021.11.003