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著者
Kamba Masayuki Department of Radiology, Faculty of Medicine, Tottori University
Suto Yuji Department of Radiology, Faculty of Medicine, Tottori University
Kodama Fumiko Department of Radiology, Faculty of Medicine, Tottori University
Sugihara Shuji Department of Radiology, Faculty of Medicine, Tottori University
Yoshida Kotaro Department of Radiology, Faculty of Medicine, Tottori University
キーワード
computed tomography
contrast enhancement
iron colloid
hepatocellular carcinoma
magnetic resonance imaging
抄録
To determine the usefulness of chondroitin sulfate iron colloid (CSIC)-enhanced magnetic resonance imaging (MRI) in evaluation of the histologic grade of hepatocellular carcinoma (HCC), we performed a comparative study with computed tomography during arterial portography (CTAP) and CT arteriography. Twenty-one surgically resected HCCs 3 cm or less in diameter were examined. There were five well- differentiated, six well- to moderately-differentiated and ten moderately- or poorly-differentiated HCCs. T2-weighted spin echo images (repetition time: 2,000 ms, echo time: 90 ms) were taken before and after intravenous injection of 23.6 ?mol Fe/kg of CSIC. The differences between precontrast and postcontrast contrast-to-noise ratios (enhancement index) was correlated with the findings of CTAP, CT arteriography and histological examination. The enhancement index increased with statistical significance as the intranodular arterial perfusion increased (P < 0.01), and as the intranodular portal perfusion decreased (P < 0.01). Though the enhancement index tended to increase as the grade of malignancy increased, no statistical significance was found. CSIC-enhanced MRI allowed a noninvasive evaluation of the intranodular reticuloendothelial function. We consider this procedure as a supplementary method for evaluation of the histologic grade of HCC prior to performing invasive procedures such as angiography and biopsy.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
40
2
開始ページ
117
終了ページ
123
発行日
1997-07
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 1997, 40(2), 117-123
部局名
医学部・医学系研究科・医学部附属病院
言語
英語