フルテキストファイル
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著者
Baba Takashi Department of Immunology and Department of Ophthalmology, Faculty of Medicine, Tottori University KAKEN
Mitsuyoshi Saori Department of Immunology, Kumamoto University School of Medicine
Igarashi Hideya Department of Immunology, Kumamoto University School of Medicine
Sakaguchi Nobuo Department of Immunology, Kumamoto University School of Medicine
キーワード
B cell
cDNA clone (LL55)
fetal development
mRNA splicing
RNP
抄録
Specific expression of various RNA-binding protein (RNP) molecules is one of the critical factors that determine the development in Drosophila melanogaster and Caenorhabditis elegans. In the present study, we found a complementary DNA clone, LL55 encoding a putative RNP. Structural comparison of nucleotide and amino acid sequences demonstrate that LL55 encoding a nuclear protein with two RNA-binding consensus motifs and the common arginine-serine repeats, is similar to the sex-determining transformer-2 (tra-2) gene of Drosophila melanogaster. The expression of 2.3 kilobase (kb) and 1.5 kb LL55 messenger RNA (mRNA) is ubiquitous in murine organs and tissues, but it is selective in the early development of fetal life. It appears as early as day 10.5 and increases until day 15 of gestation in accordance with the expression of λ5 mRNA which is involved in murine pre-B cell generation. Taking account of the selective expression and the specific regulation of RNP molecules, the finding of LL55 RNP provides a new outlook for the generation and function of the immune system.
出版者
Tottori University Faculty of Medicine
資料タイプ
学術雑誌論文
ISSN・ISBN
1346-8049
書誌ID
AA00892882
掲載誌名
Yonago Acta medica
最新掲載誌名
Yonago Acta medica
40
2
開始ページ
97
終了ページ
106
発行日
1997-07
著者版フラグ
出版社版
著作権表記
Yonago Acta medica 編集委員会
掲載情報
Yonago Acta medica. 1997, 40(2), 97-106
部局名
医学部・医学系研究科・医学部附属病院
言語
英語