フルテキストファイル
著者
Kawashima, Fumiaki Department of Biological Regulation, School of Health Science, Faculty of MedicineTottori University
Saito, Kengo Department of Biological Regulation, School of Health Science, Faculty of MedicineTottori University
Kurata, Hirofumi Department of Biological Regulation, School of Health Science, Faculty of MedicineTottori University / Division of Child Neurology, Department of Brain and Neurosciences, Faculty of MedicineTottori University 研究者総覧 KAKEN
Maegaki, Yoshihiro Division of Child Neurology, Department of Brain and Neurosciences, Faculty of MedicineTottori University 研究者総覧 KAKEN
Mori, Tetsuji Department of Biological Regulation, School of Health Science, Faculty of MedicineTottori University 研究者総覧 KAKEN
キーワード
c-Jun
Immunohistochemistry
Development
Adult neurogenesis
Status epilepticus
抄録
c-jun, a major component of AP-1 transcription factor, has a wide variety of functions. In the embryonic brain, c-jun mRNA is abundantly expressed in germinal layers around the ventricles. Although the subventricular zone (SVZ) of the adult brain is a derivative of embryonic germinal layers and contains neural precursor cells (NPCs), the c-jun expression pattern is not clear. To study the function of c-jun in adult neurogenesis, we analyzed c-jun expression in the adult SVZ by immunohistochemistry and compared it with that of the embryonic brain. We found that almost all proliferating embryonic NPCs expressed c-jun, but the number of c-jun immunopositive cells among proliferating adult NPCs was about half. In addition, c-jun was hardly expressed in post-mitotic migrating neurons in the embryonic brain, but the majority of c-jun immunopositive cells were tangentially migrating neuroblasts heading toward the olfactory bulb in the adult brain. In addition, status epilepticus is known to enhance the transient proliferation of adult NPCs, but the c-jun expression pattern was not significantly affected. These expression patterns suggest that c-jun has a pivotal role in the proliferation of embryonic NPCs, but it has also other roles in adult neurogenesis.
出版者
Springer Berlin Heidelberg
資料タイプ
学術雑誌論文
外部リンク
ISSN
09486143
書誌ID
AA11033302
掲載誌名
Histochemistry and cell biology
147
6
開始ページ
721
終了ページ
731
Original Paper
発行日
2017-01-16
出版者DOI
著者版フラグ
著者版
著作権表記
© Springer-Verlag Berlin Heidelberg 2017
掲載情報
This is a post-peer-review, pre-copyedit version of an article published in [ Kawashima, F., Saito, K., Kurata, H. et al. Histochem Cell Biol (2017) 147: 721. https://doi.org/10.1007/s00418-016-1536-2 ]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00418-016-1536-2
部局名
医学部・医学系研究科・医学部附属病院
言語
英語