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oai:repository.lib.tottori-u.ac.jp:00004744 2023-09-28T23:53:21Z 1:9 2:12 23:34:988:992

Clinical Features of Oral Multiple Primary Carcinomas Compared with Oral Single Primary Carcinoma 田村, 隆行 タムラ, タカユキ Tamura, Takayuki 藤井, 信行 フジイ, ノブユキ Fujii, Nobuyuki Doi, Rieko ドイ, リエコ 10294315 小谷, 勇 コダニ, イサム Kodani, Isamu Kawasaki, Makoto Harada, Yusei Doi, Rieko ドイ, リエコ Yonago Acta medica　編集委員会 carcinoma squamous cell mouth neoplasms neoplasms multiple primary carcinoma squamous cell mouth neoplasms neoplasms multiple primary [Background] Owing to the increase in the older population and the increased life span, the number of patients with oral multiple primary carcinomas will increase. Predicting the second and third carcinoma clinically is difficult, and the presence of second or third carcinomas is a factor that determines the prognosis of oral carcinoma. In this study, we examined the clinical features of oral multiple primary carcinomas treated in our department. [Methods] We retrospectively reviewed the medical records of patients with oral squamous cell carcinoma who underwent radical treatment at and were followed by the Department of Oral and Maxillofacial Surgery, Tottori University Hospital from January 2003 to October 2017. [Results] This study included 261 patients: 241 patients had oral single primary carcinoma and 20 patients had oral multiple primary carcinomas. Oral multiple primary carcinomas showed female predilection and occurred more frequently in the lower gingiva and significantly less frequently in the tongue (P < 0.01). Oral multiple primary carcinomas showed a significantly higher recurrence rate (P < 0.01). The 5-year overall survival of oral single primary carcinoma patients was 88.0% compared with 95% for oral multiple primary carcinomas, with no significant difference (log rank test, P = 0.54). However, the 15-year survival rate dropped to 28.1% in oral multiple primary carcinomas. The cumulative disease incidence rates of metachronous second primary carcinoma from first carcinoma at 5 years and 10 years were 3.45% and 5.36%, respectively. [Conclusion] Oral multiple primary carcinomas rarely occur in the tongue. The 5-year survival rate showed no difference between single and multiple carcinoma patients, but over longer observation, the prognosis of multiple carcinoma was poor owing to a high recurrence rate. Because of the high recurrence rate and risk of further metachronous carcinoma in oral multiple primary carcinomas, longer-term follow-up is required. Tottori University Medical Press 2020-11-24 eng journal article VoR https://repository.lib.tottori-u.ac.jp/records/4744 10.33160/yam.2020.11.002 Kawasaki Makoto, Tamura Takayuki, Harada Yusei, et al. Clinical Features of Oral Multiple Primary Carcinomas Compared with Oral Single Primary Carcinoma. Yonago Acta Medica. 2020, 63(4). 246-254. doi:10.33160/yam.2020.11.002 https://www.jstage.jst.go.jp/article/yam/63/4/63_2020.11.002/_article/ https://www.jstage.jst.go.jp/article/yam/63/4/63_2020.11.002/_article/ http://www.lib.tottori-u.ac.jp/yam/yam/yam63-4/63-4contents.html http://www.lib.tottori-u.ac.jp/yam/yam/yam63-4/63-4contents.html AA00892882 05135710 Yonago Acta Medica Yonago Acta Medica 63 4 246 254 https://repository.lib.tottori-u.ac.jp/record/4744/files/yam63(4)_246.pdf application/pdf 905.4 kB 2023-03-15