2026-03-09T15:13:46Z https://repository.lib.tottori-u.ac.jp/oai

oai:repository.lib.tottori-u.ac.jp:00004788 2023-09-28T23:55:55Z 1:9 2:12 23:34:993:995

Effect of Intravesical Bacilli Calmette-Guerin Therapy After Second Transurethral Resection in Stage Ta T1 High-Grade Bladder Cancer 20362890 ホンダ, マサシ Honda, Masashi Kimura, Yusuke 50419496 Morizane, Shuichi 50403407 Hikita, Katsuya Isoyama, Tadahiro Ono, Koji Koumi, Tsutomu Takahashi, Chihiro 50368669 Takenaka, Atsushi Yonago Acta medica　編集委員会 bacilli calmette-guerin therapy bladder cancer second transurethral resection bacilli calmette-guerin therapy bladder cancer second transurethral resection Background: To evaluate the efficacy of Bacilli Calmette-Guerin (BCG) induction instillation therapy after second transurethral resection (TUR) in stage Ta T1 high-grade bladder cancer. Methods: We performed a retrospective analysis of 49 consecutive new onset Ta T1 high-grade bladder cancer patients treated with second TUR at our affiliated institutions. Residual cancer rate, intravesical recurrence-free survival (RFS), and risk factors related to RFS were evaluated by univariate and multivariate Cox proportional hazard model analyses. Results: Thirty-one patients received BCG therapy after the second TUR (BCG group), and 18 patients were treated with second TUR alone (no BCG group). There were statistically significant differences in the RFS rates between the two groups, (P = 0.037). BCG therapy was the only factor predictive of intravesical recurrence after second TUR in both univariate and multivariate analyses. After the second TUR, BCG therapy significantly decreased intravesical recurrence in the patients with residual tumors (P = 0.014). However, there was no significant difference in intravesical recurrence in the patients with no residual tumors between the two groups (P = 0.359). Conclusion: BCG therapy after second TUR significantly decreased intravesical recurrence of residual tumors found at the second TUR. Tottori University Medical Press 2019-06-20 eng journal article VoR https://repository.lib.tottori-u.ac.jp/records/4788 10.33160/yam.2019.06.003 Yusuke Kimura, Masashi Honda, Shuichi Morizane, Katsuya Hikita, Tadahiro Isoyama, Koji Ono, Tsutomu Koumi, Chihiro Takahashi, Atsushi Takenaka, Effect of Intravesical Bacilli Calmette-Guerin Therapy After Second Transurethral Resection in Stage Ta T1 High http://www.lib.tottori-u.ac.jp/yam/yam/yam62-2/62-2contents.html http://www.lib.tottori-u.ac.jp/yam/yam/yam62-2/62-2contents.html https://www.jstage.jst.go.jp/article/yam/62/2/62_2019.06.003/_article/ https://www.jstage.jst.go.jp/article/yam/62/2/62_2019.06.003/_article/ AA00892882 05135710 Yonago Acta Medica Yonago Acta Medica 62 2 191 197 https://repository.lib.tottori-u.ac.jp/record/4788/files/yam62(2)_191.pdf application/pdf 740.5 kB 2023-03-15