2026-03-15T05:32:19Z https://repository.lib.tottori-u.ac.jp/oai

oai:repository.lib.tottori-u.ac.jp:02001990 2025-10-01T08:26:45Z 1:9 2:12 23:34:1744609014513:1759291552751

Localized Nodular Amyloidosis of the Buccal Mucosa Associated with Sjögren’s Syndrome : A Case Report and Literature Review 20294316 Doi,Rieko 土井,理恵子 15101 鳥取大学 Tottori University Shimizu,Kiharu 15101 鳥取大学 Tottori University Fujii,Nobuyuki 藤井,信行 15101 鳥取大学 Tottori University 21020653 Sakai,Kosuke 酒井,皓介 15101 鳥取大学 Tottori University 80816372 Kawasaki,Makoto 川崎,誠 15101 鳥取大学 Tottori University Tamura,Takayuki 田村,隆行 15101 鳥取大学 Tottori University 10294315 Kodani,Isamu 小谷,勇 15101 鳥取大学 Tottori University open access © 2025 Tottori University Medical Press AL amyloidosis localized nodular amyloidosis oral Sjögren’s syndrome Amyloidosis is a group of disorders in which specific precursor proteins form insoluble amyloid fibrils are deposited in various organs and extracellular spaces. Sjögren’s syndrome (SS) is a chronic inflammatory disease in which lymphocytes infiltrate the exocrine glands, such as the salivary and lacrimal glands, through an autoimmune mechanism. At advanced stages of SS, localized nodular amyloidosis has been reported in specific organs outside the glands. Herein, we report a case of localized nodular amyloidosis associated with SS. An 80-year-old woman, who had been biting her buccal mucosa for several years and was aware of the presence of a mass, which had increased in size since approximately 6 months, was referred to our hospital. The patient had a history of SS and systemic lupus erythematosus since her 50s. A needle biopsy was performed because malignancy was suspected by magnetic resonance imaging. The pathological diagnosis was ATTR-type amyloidosis. The patient underwent excision of the lesion to improve the swelling. The pathological　findings showed plasma cell infiltration in some areas, which required differentiation from AL amyloidosis; therefore, the patient was referred to a facility specializing in amyloidosis. The pathological diagnosis was AL amyloidosis. Various　clinical findings ruled out systemic involvement and the final pathological diagnosis was localized nodular amyloidosis. It has been reported that it may occur in the advanced stages of SS, and our patient had SS for 30 years. One year after the surgery, the patient’s prognosis was good. Tottori University Medical Press 2025-08-22 2025-08-22 eng journal article VoR https://repository.lib.tottori-u.ac.jp/records/2001990 https://doi.org/10.33160/yam.2025.08.009 https://www.lib.tottori-u.ac.jp/yam/yam/yam68-3/68-3contents.html 13468049 Yonago Acta Medica 68 3 8 289 296 https://repository.lib.tottori-u.ac.jp/record/2001990/files/yam68(3)_289.pdf application/pdf 2.4 MB 2025-09-09 2025-08-22