2026-03-08T00:35:57Z https://repository.lib.tottori-u.ac.jp/oai

oai:repository.lib.tottori-u.ac.jp:00004823 2023-09-28T23:57:51Z 1:9 2:12 23:34:998:1000

Indirubin, a Constituent of the Chinese Herbal Medicine Qing-Dai, Attenuates Dextran Sulfate Sodium-induced Murine Colitis Tokuyasu, Naruo Tokuyasu, Naruo 60314572 Shomori, Kohei Shomori, Kohei Amano, Kuniki Honjo, Soichiro Honjo, Soichiro Sakamoto, Teruhisa Sakamoto, Teruhisa Watanabe, Joji Watanabe, Joji 40790374 Amisaki, Masataka Amisaki, Masataka 40808953 Morimoto, Masaki Morimoto, Masaki Uchinaka, Ei Yagyu, Takuki 20335532 Saito, Hiroaki Saito, Hiroaki 60127610 Ito, Hisao Ito, Hisao 40314330 Fujiwara, Yoshiyuki Fujiwara, Yoshiyuki Amano, Kuniki Uchinaka, Ei Yagyu, Takuki Yonago Acta medica　編集委員会 Chinese herbal medicine DSS-induced colitis model indirubin inflammatory bowel disease Qing-Dai Chinese herbal medicine DSS-induced colitis model indirubin inflammatory bowel disease Qing-Dai 【Background】Indirubin, a constituent of the Chinese herbal medicine “Qing-Dai,” has anti-cancer and anti-inflammatory activities. We aimed to evaluate the efficacy of indirubin for ameliorating colonic inflammation in a mouse model of inflammatory bowel disease. 【Methods】Mice with dextran sulfate sodium (DSS)induced acute and chronic colitis were treated with indirubin in their diet. Clinical and histologic changes were evaluated. In addition, colon levels of interleukin-6, a critical pro-inflammatory mediator, was detected by enzyme-linked immunosorbent assay. 【Results】In the model of acute colitis, indirubin treatment improved the loss of body weight. Histology of colonic tissue revealed that indirubin treatment improved the histology grading of colitis (P = 0.02), the extent of submucosal fibrosis (P = 0.018), the number of mucosal toluidine blue-positive cells (P = 0.004) and colon length (P = 0.01). In the model of chronic colitis, indirubin treatment had no significant effect on pathologic findings except for colon length (P = 0.003). However, indirubin administration significantly reduced colon levels of interleukin-6 in the chronic-colitis model (P = 0.001). 【Conclusion】Our study clearly showed that oral intake of indirubin can improve murine DSS-induced colitis (which mimics human inflammatory bowel disease). Tottori University Faculty of Medicine 2018-06-18 eng journal article VoR https://repository.lib.tottori-u.ac.jp/records/4823 10.33160/yam.2018.06.005 Yonago Acta Medica. 2018,61(2), 128-136 http://www.lib.tottori-u.ac.jp/yam/yam/yam61-2/61-2contents.html http://www.lib.tottori-u.ac.jp/yam/yam/yam61-2/61-2contents.html AA00892882 05135710 Yonago Acta Medica Yonago Acta Medica 61 2 128 136 https://repository.lib.tottori-u.ac.jp/record/4823/files/yam61(2)_128.pdf application/pdf 2.6 MB 2018-06-20