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Allele-Specific Expression Analysis of PEG1/MEST in Head and Neck Squamous Cell Carcinomas 00224436 Kataoka, Hideyuki Kataoka, Hideyuki Nakano, Seiji 20444630 Kunimoto, Yasuomi Kunimoto, Yasuomi Sugie, Naoko 40325006 Osaki, Mitsuhiko Osaki, Mitsuhiko Uzawa, Narikazu Yoshida, Mitsuaki A. 20111619 Oshimura, Mitsuo Oshimura, Mitsuo Kitano, Hiroya Nakano, Seiji Sugie, Naoko Uzawa, Narikazu Yoshida, Mitsuaki A. Kitano, Hiroya Yonago Acta medica　編集委員会 head and neck squamous cell carcinoma loss of imprinting PEG1/MEST head and neck squamous cell carcinoma loss of imprinting PEG1/MEST Genomic imprinting is an epigenetic feature that plays a significant role in carcinogenesis. In this study, we examined the expression status of an imprinted gene, paternally expressed gene 1/mesoderm-specific transcript PEG1/MEST, in 38 cases of head and neck squamous cell carcinomas (HNSCCs) and in 17 oral squamous cancer cell lines. Loss of imprinting (LOI) of PEG1/MEST was found in 8 of 10 (80%) in tumor specimens, and 6 of 10 (60%) informative cases even in the extracted normal tissue specimens. As for the oral squamous cancer cell lines, LOI was detected in 5 of 8 (62.5%) informative cases in PEG1/MEST. Thus, these data showed that abnormal expression of PEG1/MEST was found at a high frequency in the tumor, the extracted normal tissue specimens and the oral squamous cancer cell lines. PEG1/MEST LOI in extracted normal tissue specimens may have a potential individual cancer risk for HNSCC. Tottori University Faculty of Medicine 2009-06 eng journal article VoR https://repository.lib.tottori-u.ac.jp/records/5028 Yonago Acta medica. 2009, 52(2), 85-90 AA00892882 13468049 Yonago Acta medica Yonago Acta medica 52 2 85 90 https://repository.lib.tottori-u.ac.jp/record/5028/files/52_085-090.pdf application/pdf 152.9 kB 2009-07-30