2026-03-15T20:25:27Z https://repository.lib.tottori-u.ac.jp/oai

oai:repository.lib.tottori-u.ac.jp:00005075 2023-10-03T23:52:45Z 1:9 2:12 23:34:1063:1064

EBV-Associated Diseases in Humans and their Animal in vivo Models: Part I 30180962 Hayashi, Kazuhiko Hayashi, Kazuhiko Yonago Acta medica　編集委員会 animal mode EBV-associated disease human; lymphocryptovirus animal mode EBV-associated disease human; lymphocryptovirus Epstein-Barr virus (EBV) is one of human herpesviruses and a member of the gamma herpesvirus family (lymphocryptovirus). Infectious mononucleosis, Burkitt's lymphoma and nasopharyngeal carcinoma are well-known EBV-associated diseases. The range of EBV-associated diseases has recently expanded to include Hodgkin's lymphoma, T-cell lymphoma, pyothorax-associated or methotrexate-associated B-cell lymphoma, primary effusion lymphoma and lymphoepithelioma-like carcinoma of the stomach, thymus and salivary gland, lymphoproliferative disorders (LPDs) or leiomyosarcomas from immunocompromized host, oral hairy leukoplakia and EBV-associated hemophagocytic syndrome. Animal models of human EBV-associated diseases are essential to elucidate the pathogenesis of EBV-infection and EBV-associated diseases. However, only several reports on the animal models of EBV infection have been reported. Here I review the summary of EBV-associated diseases in humans and those previous animal models using EBV or EBV-like herpesviruses and describe some details on our two newly developed rabbit models of LPD induced by simian EBV-like viruses and a mouse model with murine gammaherpesvirus. These animal models are useful and inexpensive alternative experimental model systems for studying the biology and pathogenesis of EBV, and prophylactic and therapeutic regimens. Tottori University Faculty of Medicine 2005-03 eng journal article VoR https://repository.lib.tottori-u.ac.jp/records/5075 Yonago Acta medica. 2005, 48(1), 1-6 AA00892882 13468049 Yonago Acta medica Yonago Acta medica 48 1 1 6 https://repository.lib.tottori-u.ac.jp/record/5075/files/48_001-006.pdf application/pdf 239.1 kB 2009-06-09