2026-03-14T14:33:03Z https://repository.lib.tottori-u.ac.jp/oai

oai:repository.lib.tottori-u.ac.jp:02001490 2024-10-18T07:01:01Z 1:9 2:12 23:34:1710471377862:1725515186456

Combination Biologic Therapy with Mepolizumab and Dupilumab for Severe Eosinophilic Granulomatosis with Polyangiitis and Chronic Rhinosinusitis with Nasal Polyp 中村,陽祐 Nakamura,Yosuke ナカムラ,ヨウスケ 中村 Nakamura ナカムラ 陽祐 Yosuke ヨウスケ 15101 鳥取大学 Tottori University Kikumoto,Naoki Kikumoto Naoki 40197273 竹内,裕美 Takeuchi,Hiromi タケウチ,ヒロミ 竹内 Takeuchi タケウチ 裕美 Hiromi ヒロミ Kimura,Toru Kimura Toru 15101 鳥取大学 Tottori University Nakamori,Motoki Nakamori Motoki 15101 鳥取大学 Tottori University 90403419 藤原,和典 Fujiwara,Kazunori フジワラ,カズノリ 藤原 Fujiwara フジワラ 和典 Kazunori カズノリ 15101 鳥取大学 Tottori University open access (C)2024 Tottori University Medical Press asthma biologic therapy combination therapy eosinophilic granulomatosis with polyangiitis rhinosinusitis We report the case of a 55-year-old female with eosinophilic granulomatosis with polyangiitis and chronic rhinosinusitis with nasal polyp. Rhinosinusitis recurred 6 months after full-house endoscopic sinus surgery. Although conventional treatment with azathioprine and mepolizumab with steroids was given, it was difficult to simultaneously control both rhinosinusitis and eosinophilic granulomatosis with polyangiitis. Clinical examinations showed polyps in the olfactory cleft, and the patient’s anosmia gradually became persistent. Even after administering mepolizumab for a certain period of time, symptoms did not improve, but when the biologic agent was switched to dupilumab, an improvement in recalcitrant chronic rhinosinusitis with nasal polyp was observed. While dupilumab was administered intermittently for refractory chronic rhinosinusitis with nasal polyp, the rhinosinusitis improved and symptoms such as worsening of eosinophilic granulomatosis with polyangiitis paresthesia were observed. Both symptoms gradually subsided 19 months after starting intermittent administration, leading to the discontinuation of dupilumab administration. Rhinosinusitis in the setting of eosinophilic granulomatosis with polyangiitis may be refractory in some cases, and this case provides findings demonstrating the strong effect of dupilumab on eosinophilic inflammation. Tottori University Medical Press 2024-05-28 eng journal article VoR https://repository.lib.tottori-u.ac.jp/records/2001490 Yonago Acta Medica. 2024, 67(2), 157-162. https://www.lib.tottori-u.ac.jp/yam/yam/yam67-2/67-2contents.html https://www.lib.tottori-u.ac.jp/yam/yam/yam67-2/67-2contents.html https://doi.org/10.33160/yam.2024.05.005 https://doi.org/10.33160/yam.2024.05.005 AA00892882 05135710 13468049 Yonago Acta Medica 67 2 6 157 162 https://repository.lib.tottori-u.ac.jp/record/2001490/files/yam67(2)_157.pdf application/pdf 1.3 MB 2024-05-28 2024-05-28