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Mineralization of hydroxyapatite upon a unique xanthan gum hydrogel by an alternate soaking process Izawa, Hironori 4641 50643235 100000923 Nishio, Shoji 26391 Maeda, Hiroyuki 26392 Morita, Kohei 26393 Ifuku, Shinsuke 4637 70402980 100000469 Morimoto, Minoru 2273 10273880 100000741 Saimoto, Hiroyuki 4721 20186977 100000515 Kadokawa, Jun-ichi 26394 Xanthan gum Hydroxyapatite Alternate soaking process Inorganic–organic composite hydrogel Mineralization Xanthan gum Hydroxyapatite Alternate soaking process Inorganic–organic composite hydrogel Mineralization We previously reported a xanthan gum (Xan) hydrogel showing excellent mechanical properties. Mineralization of hydroxyapatite (Hap) upon the Xan hydrogel would provide a unique biomaterial applicable for bone tissue engineering. Here, we show the mineralization of Hap upon the Xan hydrogel by means of an alternate soaking process. Hap was gradually grown upon the Xan-matrix surface with increasing number of soaking cycles due to the ionic interactions between calcium cations and carboxyl groups. Interestingly, the mineralization induced a microstructure change in the gel-matrix from a layered structure to a porous structure. The mechanical properties of the resulting Hap–Xan composite hydrogels were further investigated by a tensile test, where the Hap–Xan composite hydrogel with an appropriate amount of Hap (Xan/Hap = 2.7) was capable of approximately 370% elongation. journal article Elsevier Ltd. 2014-02-15 AM application/pdf Carbohydrate Polymers 102 846 851 Carbohydrate Polymers AA11522761 01448617 https://repository.lib.tottori-u.ac.jp/record/7126/files/cp102_846.pdf https://repository.lib.tottori-u.ac.jp/records/7126 eng 10.1016/j.carbpol.2013.10.080 This research was published by Elsevier Ltd.: IZAWA, Hironori, et al. Mineralization of hydroxyapatite upon a unique xanthan gum hydrogel by an alternate soaking process. Carbohydrate polymers, 2014, 102: 846-851. https://doi.org/10.1016/j.carbpol.2013.10 https://www.sciencedirect.com/science/article/pii/S0144861713011090 https://www.sciencedirect.com/science/article/pii/S0144861713011090 Copyright © 2014 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/