{"created":"2023-11-09T07:48:57.211255+00:00","id":2000577,"links":{},"metadata":{"_buckets":{"deposit":"bee1c499-c30f-4baa-a5fd-f33325e6e1e7"},"_deposit":{"created_by":10,"id":"2000577","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2000577"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:02000577","sets":["1:9","2:12","23:34:975:1699575635565"]},"author_link":["4867"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-08-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicNumberOfPages":"10","bibliographicPageEnd":"374","bibliographicPageStart":"365","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Voriconazole therapy for fungal infections usually continues for several years and is often administered on an outpatient basis. Maintaining the voriconazole plasma concentration in the therapeutic range is highly important for effective therapy; however, it is difficult to obtain sufficient information to assess the voriconazole concentration in outpatients. Therefore, we developed a method to simultaneously measure the plasma concentrations of voriconazole and its major metabolite, voriconazole N-oxide, to obtain rapid results after outpatient blood collection and before medical consultation and to attain a better understanding of adherence and the drug-drug interactions of voriconazole. Methods: Fifty microliters of patient plasma was deproteinized with methanol, injected into the liquid chromatography-tandem mass spectrometry system, and purified using an online column. Separation was achieved on an InertSustain C18 column (2.1 mm id x 50 mm, 2 mu m) with a mobile phase of 30:70 (0.1% formic acid in water:methanol) at a flow rate of 0.2 mL/min. Detection was performed using electrospray ionization in positive ion multiple reaction monitoring mode. Results: The analysis time was 4 min. The calibration curve was linear, in the range of 0.1 mu g/mL to 20 mu g/mL for voriconazole and 0.05 mu g/mL to 10 mu g/mL for voriconazole N-oxide, with a coefficient of determination at R-2 > 0.999. Conclusion: There is no need to dilute the patient's plasma even if the concentration of voriconazole is near the upper limit of measurement. Furthermore, the short measurement-time could immediately inform physicians of the patient's voriconazole concentration during ambulatory medical care. Simultaneous measurement of voriconazole and voriconazole N-oxide may also be useful for the immediate adjustment of voriconazole dosage in outpatients and would help us to understand adherence or drug-drug interactions in plasma voriconazole concentrations.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Medical Press","subitem_publisher_language":"en"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta Medica. 2023, 66(3), 365-374."}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam66-3/66-3contents.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam66-3/66-3contents.html","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.33160/yam.2023.08.009"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.33160/yam.2023.08.009","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C)2023 Tottori University Medical Press","subitem_rights_language":"en"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"PISSN"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Pharmacy, Tottori University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Pharmacy, Tottori University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Pharmacy, Tottori University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Pharmacy, Tottori University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Pharmacy, Tottori University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Pharmacy, Tottori University Hospital"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"15101","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"鳥取大学","affiliationNameLang":"ja"},{"affiliationName":"Tottori 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University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Fujiyoshi,Masachika","creatorNameLang":"en"}],"familyNames":[{"familyName":"Fujiyoshi","familyNameLang":"en"}],"givenNames":[{"givenName":"Masachika","givenNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"15101","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"鳥取大学","affiliationNameLang":"ja"},{"affiliationName":"Tottori University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"島田,美樹","creatorNameLang":"ja"},{"creatorName":"Shimada,Miki","creatorNameLang":"en"},{"creatorName":"シマダ,ミキエ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"島田","familyNameLang":"ja"},{"familyName":"Shimada","familyNameLang":"en"},{"familyName":"シマダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"美樹","givenNameLang":"ja"},{"givenName":"Miki","givenNameLang":"en"},{"givenName":"ミキエ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4867","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100001255","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001255ja.html"},{"nameIdentifier":"10196488","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10196488"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-08-25"}],"displaytype":"detail","fileDate":[{"fileDateType":"Issued","fileDateValue":"2023-08-25"}],"filename":"yam66(3)_365.pdf","format":"application/pdf","licensefree":"(C)2023 Tottori University Medical Press","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"yam66(3)_365.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/2000577/files/yam66(3)_365.pdf"},"version_id":"380712a0-d5ae-49f2-988d-03b8ec94093b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"liquid chromatography","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tandem mass spectrometry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"therapeutic drug monitoring","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"voriconazole","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Development of a New Method for Simultaneous Quantitation of Plasma Concentrations of Voriconazole and Voriconazole N-Oxide Using Column-Switching LC-MS/MS and Its Application in Therapeutic Drug Monitoring","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of a New Method for Simultaneous Quantitation of Plasma Concentrations of Voriconazole and Voriconazole N-Oxide Using Column-Switching LC-MS/MS and Its Application in Therapeutic Drug Monitoring","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1699575635565"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-22"},"publish_date":"2023-11-22","publish_status":"0","recid":"2000577","relation_version_is_last":true,"title":["Development of a New Method for Simultaneous Quantitation of Plasma Concentrations of Voriconazole and Voriconazole N-Oxide Using Column-Switching LC-MS/MS and Its Application in Therapeutic Drug Monitoring"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-12-11T23:52:16.471488+00:00"}