@article{oai:repository.lib.tottori-u.ac.jp:02001327,
 author = {Okuno,Masayuki and 榎田,誠 and Enokida,Makoto and 柳樂,慶太 and Nagira,Keita and 永島,英樹 and Nagashima,Hideki},
 issue = {1},
 journal = {Yonago Acta Medica},
 month = {Feb},
 note = {Background: This study aimed to evaluate the effect of chitin nanofibers (CNF) produced from crab shells as a medical material for the knee in an osteoarthritic rat model. Methods: The effect of intra-articular CNF injection was evaluated histologically among three groups: saline, hyaluronic acid (HA), and CNF injection groups. The Osteoarthritis Research Society International (OARSI) cartilage, subchondral bone, synovial, and meniscus scores were used for scoring. Results: At 4 weeks, the CNF group had significantly lower scores than the saline group. The Synovial score was lower in HA and CNF groups at 4 weeks than in the saline group. At 4 weeks post-treatment, the thickening of the subchondral bone plate and angiogenesis were significantly reduced in the CNF treatment group compared to those in the saline treatment group (P = 0.02). Conclusion: The anti-inflammatory effects of CNF on knee osteoarthritis were comparable to that of HA in the early stages.},
 pages = {22--30},
 title = {Intra-Articular Injection of Chitin Nanofiber Attenuates Osteoarthritis: An Experimental Study in a Rat Model of Osteoarthritis},
 volume = {67},
 year = {2024},
 yomi = {エノキダ,マコト and ナギラ,ケイタ and ナガシマ,ヒデキ}
}