{"created":"2025-01-27T04:54:53.285166+00:00","id":2001696,"links":{},"metadata":{"_buckets":{"deposit":"3c6f905d-6cbd-475c-ad98-e594080e48e7"},"_deposit":{"created_by":10,"id":"2001696","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2001696"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:02001696","sets":["1:7","2:12"]},"author_link":["4668"],"item_30002_access_rights4":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_30002_bibliographic_information29":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-07-27","bibliographicIssueDateType":"Issued"},"bibliographicNumberOfPages":"7","bibliographicPageEnd":"19","bibliographicPageStart":"13","bibliographicVolumeNumber":"677","bibliographic_titles":[{"bibliographic_title":"Biochemical and biophysical research 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However, as some cancer cells are resistant to statins, broadening an anticancer spectrum of statins is desirable. The upregulated expression of the statin target enzyme, 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase (HMGCR), in statin-treated cancer cells is a well-known mechanism of statin resistance, which can be counteracted by the downregulation of HMGCR gene expression, or degradation of the HMGCR protein. However, the mechanism by which HMGCR degradation influences the anticancer effects of statins remain unreported. We tested the effect of the HMGCR degrader compound SR-12813 at a concentration that did not affect the growth of eight diverse tumor cell lines. Combined treatment with atorvastatin and a low concentration of SR-12813 led to lowering of increased HMGCR expression, and augmented the cytostatic effect of atorvastatin in both statin-resistant and -sensitive cancer cells compared with that of atorvastatin treatment alone. Dual-targeting of HMGCR using statins and SR-12813 (or similar compounds) could provide an improved anticancer therapeutic approach.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_30002_file35":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-07-27"}],"displaytype":"detail","fileDate":[{"fileDateType":"Issued","fileDateValue":"2023-07-27"}],"filename":"bbrc677_13.pdf","filesize":[{"value":"3.9 MB"}],"format":"application/pdf","licensefree":"(C) 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://repository.lib.tottori-u.ac.jp/record/2001696/files/bbrc677_13.pdf"},"version_id":"0c854fce-ad6d-4640-8747-9caf57624062"}]},"item_30002_language12":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30002_number_of_pages26":{"attribute_name":"ページ数","attribute_value_mlt":[{"subitem_number_of_pages":"7"}]},"item_30002_page_end28":{"attribute_name":"終了ページ","attribute_value_mlt":[{"subitem_end_page":"19"}]},"item_30002_page_start27":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"13"}]},"item_30002_publisher10":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier BV","subitem_publisher_language":"en"}]},"item_30002_relation18":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bbrc.2023.07.056","subitem_relation_type_select":"DOI"}}]},"item_30002_resource_type13":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_30002_rights6":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"(C) 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_30002_source_identifier22":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"10902104","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"0006291x","subitem_source_identifier_type":"PISSN"}]},"item_30002_source_title23":{"attribute_name":"収録物名","attribute_value_mlt":[{"subitem_source_title":"Biochemical and biophysical research communications","subitem_source_title_language":"en"}]},"item_30002_subject8":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"Statin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SR-12813","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cancer cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HMGCR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dual inhibition","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Targeted protein degradation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30002_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HMG-CoA reductase degrader, SR-12813, counteracts statin-induced upregulation of HMG-CoA reductase and augments the anticancer effect of atorvastatin","subitem_title_language":"en"}]},"item_30002_version_type15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_30002_volume_number24":{"attribute_name":"巻","attribute_value_mlt":[{"subitem_volume":"677"}]},"item_title":"HMG-CoA reductase degrader, SR-12813, counteracts statin-induced upregulation of HMG-CoA reductase and augments the anticancer effect of atorvastatin","item_type_id":"30002","owner":"10","path":["12","7"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-02-12"},"publish_date":"2025-02-12","publish_status":"0","recid":"2001696","relation_version_is_last":true,"title":["HMG-CoA reductase degrader, SR-12813, counteracts statin-induced upregulation of HMG-CoA reductase and augments the anticancer effect of atorvastatin"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2025-02-13T08:18:24.348379+00:00"}