{"created":"2025-01-27T04:54:58.597342+00:00","id":2001697,"links":{},"metadata":{"_buckets":{"deposit":"db3e6483-b22a-436a-9e66-a4d692286f3c"},"_deposit":{"created_by":10,"id":"2001697","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2001697"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:02001697","sets":["1:7","2:12"]},"author_link":["4668"],"item_30002_access_rights4":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_30002_bibliographic_information29":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-07-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageStart":"e18017","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Heliyon","bibliographic_titleLang":"en"}]}]},"item_30002_creator2":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Irie,Nanami","creatorNameLang":"en","creatorNameType":"Personal"}],"familyNames":[{"familyName":"Irie","familyNameLang":"en"}],"givenNames":[{"givenName":"Nanami","givenNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"15101","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"鳥取大学","affiliationNameLang":"ja"},{"affiliationName":"Tottori University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"割田,克彦","creatorNameLang":"ja","creatorNameType":"Personal"},{"creatorName":"Warita,Katsuhiko","creatorNameLang":"en","creatorNameType":"Personal"},{"creatorName":"ワリタ,カツヒコ","creatorNameLang":"ja-Kana","creatorNameType":"Personal"}],"familyNames":[{"familyName":"割田","familyNameLang":"ja"},{"familyName":"Warita","familyNameLang":"en"},{"familyName":"ワリタ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"克彦","givenNameLang":"ja"},{"givenName":"Katsuhiko","givenNameLang":"en"},{"givenName":"カツヒコ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4668","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100001516","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001516_ja.html"},{"nameIdentifier":"40452669","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40452669"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"15101","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"鳥取大学","affiliationNameLang":"ja"},{"affiliationName":"Tottori University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Tashiro,Jiro","creatorNameLang":"en","creatorNameType":"Personal"}],"familyNames":[{"familyName":"Tashiro","familyNameLang":"en"}],"givenNames":[{"givenName":"Jiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Zhou,Yaxuan","creatorNameLang":"en","creatorNameType":"Personal"}],"familyNames":[{"familyName":"Zhou","familyNameLang":"en"}],"givenNames":[{"givenName":"Yaxuan","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishikawa,Takuro","creatorNameLang":"en","creatorNameType":"Personal"}],"familyNames":[{"familyName":"Ishikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Takuro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Oltvai,Zoltán N","creatorNameLang":"en","creatorNameType":"Personal"}],"familyNames":[{"familyName":"Oltvai","familyNameLang":"en"}],"givenNames":[{"givenName":"Zoltán N","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Warita,Tomoko","creatorNameLang":"en","creatorNameType":"Personal"}],"familyNames":[{"familyName":"Warita","familyNameLang":"en"}],"givenNames":[{"givenName":"Tomoko","givenNameLang":"en"}]}]},"item_30002_date11":{"attribute_name":"日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-07-08","subitem_date_issued_type":"Issued"}]},"item_30002_description9":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Statins have anticancer effects and may be used as anticancer agents via drug repositioning. In reverse transcription-quantitative polymerase chain reaction (RT-qPCR) assays, the internal reference gene must not be affected by any experimental conditions. As statins exert a wide range of effects on cells by inhibiting the mevalonate pathway, it is possible that statin treatment might alter the expression of housekeeping genes used as internal reference genes, thereby misleading the assessment of obtained gene expression data. Here, we evaluated the expression stability of internal reference genes in atorvastatin-treated cancer cell lines. We treated both statin-sensitive and statin-resistant cancer cell lines with atorvastatin at seven different concentrations and performed RT-qPCR on 15 housekeeping genes whose expression stability was then assessed using five different algorithms. In both statin-sensitive and statin-resistant cancer cell lines, atorvastatin affected the expression of certain internal reference genes in a dose-dependent and cancer cell line-dependent manner; therefore, caution should be exercised when comparing target gene expression between cells. Our findings emphasize the importance of the validation of internal reference genes in gene expression analyses in drug treatment-based cancer research.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_30002_file35":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-07-08"}],"displaytype":"detail","fileDate":[{"fileDateType":"Issued","fileDateValue":"2023-07-08"}],"filename":"heliyon9(7)_e18017.pdf","filesize":[{"value":"5.2 MB"}],"format":"application/pdf","licensefree":"(C) 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). ","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://repository.lib.tottori-u.ac.jp/record/2001697/files/heliyon9(7)_e18017.pdf"},"version_id":"3709d637-b988-4826-8cdc-2aef0dcdcf9b"}]},"item_30002_issue_number25":{"attribute_name":"号","attribute_value_mlt":[{"subitem_issue":"7"}]},"item_30002_language12":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30002_page_start27":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"e18017"}]},"item_30002_publisher10":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier BV","subitem_publisher_language":"en"}]},"item_30002_relation18":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.heliyon.2023.e18017","subitem_relation_type_select":"DOI"}}]},"item_30002_resource_type13":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_30002_rights6":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"(C) 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). ","subitem_rights_language":"en"}]},"item_30002_source_identifier22":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"24058440","subitem_source_identifier_type":"EISSN"}]},"item_30002_source_title23":{"attribute_name":"収録物名","attribute_value_mlt":[{"subitem_source_title":"Heliyon","subitem_source_title_language":"en"}]},"item_30002_subject8":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"Mevalonate pathway","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cancer cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Statins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Housekeeping genes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"RT-qPCR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Optimal internal reference genes","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30002_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of housekeeping genes varies depending on mevalonate pathway inhibition in cancer cells","subitem_title_language":"en"}]},"item_30002_version_type15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_30002_volume_number24":{"attribute_name":"巻","attribute_value_mlt":[{"subitem_volume":"9"}]},"item_title":"Expression of housekeeping genes varies depending on mevalonate pathway inhibition in cancer cells","item_type_id":"30002","owner":"10","path":["12","7"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-02-12"},"publish_date":"2025-02-12","publish_status":"0","recid":"2001697","relation_version_is_last":true,"title":["Expression of housekeeping genes varies depending on mevalonate pathway inhibition in cancer cells"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2025-02-13T08:18:29.656600+00:00"}