{"created":"2025-01-27T04:55:27.875832+00:00","id":2001702,"links":{},"metadata":{"_buckets":{"deposit":"eedcbe0c-3b85-4611-9d20-82f1a3a6a466"},"_deposit":{"created_by":10,"id":"2001702","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2001702"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:02001702","sets":["1:7","2:12"]},"author_link":["4880"],"item_30002_access_rights4":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_30002_bibliographic_information29":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-10-24","bibliographicIssueDateType":"Issued"},"bibliographicNumberOfPages":"11","bibliographicPageEnd":"373","bibliographicPageStart":"363","bibliographicVolumeNumber":"91","bibliographic_titles":[{"bibliographic_title":"Acta Veterinaria Brno","bibliographic_titleLang":"en"}]}]},"item_30002_creator2":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sahashi,Yu","creatorNameLang":"en","creatorNameType":"Personal"}],"familyNames":[{"familyName":"Sahashi","familyNameLang":"en"}],"givenNames":[{"givenName":"Yu","givenNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"15101","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"鳥取大学","affiliationNameLang":"ja"},{"affiliationName":"Tottori University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"日笠,喜朗","creatorNameLang":"ja","creatorNameType":"Personal"},{"creatorName":"Hikasa,Yoshiaki","creatorNameLang":"en","creatorNameType":"Personal"},{"creatorName":"ヒカサ,ヨシアキ","creatorNameLang":"ja-Kana","creatorNameType":"Personal"}],"familyNames":[{"familyName":"日笠","familyNameLang":"ja"},{"familyName":"Hikasa","familyNameLang":"en"},{"familyName":"ヒカサ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"喜朗","givenNameLang":"ja"},{"givenName":"Yoshiaki","givenNameLang":"en"},{"givenName":"ヨシアキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4880","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000653","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000653_ja.html"},{"nameIdentifier":"30165071","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30165071"}]}]},"item_30002_date11":{"attribute_name":"日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-10-24","subitem_date_issued_type":"Issued"}]},"item_30002_description9":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The purpose of this pilot study was to assess the efficacy of long-term masitinib therapy at low doses on echocardiographic, cardiovascular, haematological, and blood biochemical indicators, as well as clinical symptoms in dogs with pulmonary hypertension (PH) caused by advanced chronic degenerative mitral valve disease or heartworm disease. Seven client-owned dogs with severe PH were recruited prospectively and given low-dose masitinib orally, 3 mg/kg body weight (approximately one-fourth of the recommended antineoplastic dosage), q24h, for 123–928 days. Examinations were performed prior to masitinib administration, as well as 1, 2, 3, 6, and 12 months later. At 1–12 months, low-dose masitinib significantly reduced systolic pulmonary arterial pressure (P < 0.05 or 0.01) and dramatically improved clinical symptoms. Low-dose masitinib treatment improved right ventricular function indicators such as right atrium/aorta ratio, maximum tricuspid regurgitation velocity, right ventricular Tei index, and tricuspid annular plane systolic excursion, without worsening left ventricular function indicators. These findings suggest that low-dose masitinib may be effective as an adjunctive therapeutic for chronic heart failure in dogs with PH and may increase the survival of PH dogs.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_30002_file35":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-10-24"}],"displaytype":"detail","fileDate":[{"fileDateType":"Issued","fileDateValue":"2022-10-24"}],"filename":"avb_91(4)_363.pdf","filesize":[{"value":"433.1 KB"}],"format":"application/pdf","licensefree":"This work is licensed under a Creative Commons Attribution 4.0 International License.","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://repository.lib.tottori-u.ac.jp/record/2001702/files/avb_91(4)_363.pdf"},"version_id":"a3d1df76-8788-4d77-996d-54978736de82"}]},"item_30002_language12":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30002_number_of_pages26":{"attribute_name":"ページ数","attribute_value_mlt":[{"subitem_number_of_pages":"11"}]},"item_30002_page_end28":{"attribute_name":"終了ページ","attribute_value_mlt":[{"subitem_end_page":"373"}]},"item_30002_page_start27":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"363"}]},"item_30002_publisher10":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"University of Veterinary and Pharmaceutical Sciences","subitem_publisher_language":"en"}]},"item_30002_relation18":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2754/avb202291040363","subitem_relation_type_select":"DOI"}}]},"item_30002_resource_type13":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_30002_rights6":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution 4.0 International License.","subitem_rights_language":"en"}]},"item_30002_source_identifier22":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"18017576","subitem_source_identifier_type":"PISSN"}]},"item_30002_source_title23":{"attribute_name":"収録物名","attribute_value_mlt":[{"subitem_source_title":"Acta Veterinaria Brno","subitem_source_title_language":"en"}]},"item_30002_subject8":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"Chronic heart failure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tyrosine kinase inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pulmonary arterial pressure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"right ventricular function","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30002_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effectiveness of therapy with low-dosage masitinib on pulmonary hypertension in dogs: a pilot study","subitem_title_language":"en"}]},"item_30002_version_type15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_30002_volume_number24":{"attribute_name":"巻","attribute_value_mlt":[{"subitem_volume":"91"}]},"item_title":"Effectiveness of therapy with low-dosage masitinib on pulmonary hypertension in dogs: a pilot study","item_type_id":"30002","owner":"10","path":["12","7"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-02-12"},"publish_date":"2025-02-12","publish_status":"0","recid":"2001702","relation_version_is_last":true,"title":["Effectiveness of therapy with low-dosage masitinib on pulmonary hypertension in dogs: a pilot study"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2025-02-13T08:19:01.021205+00:00"}