{"created":"2025-01-27T04:55:44.519854+00:00","id":2001705,"links":{},"metadata":{"_buckets":{"deposit":"d36de612-d80b-4209-96fa-20c858eaec64"},"_deposit":{"created_by":10,"id":"2001705","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2001705"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:02001705","sets":["1:7","2:12"]},"author_link":["4859"],"item_30002_access_rights4":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_30002_bibliographic_information29":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-02-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"117191","bibliographicVolumeNumber":"81","bibliographic_titles":[{"bibliographic_title":"Bioorganic & medicinal chemistry","bibliographic_titleLang":"en"}]}]},"item_30002_creator2":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"15101","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"鳥取大学","affiliationNameLang":"ja"},{"affiliationName":"Tottori University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Uemura,Asumi","creatorNameLang":"en","creatorNameType":"Personal"}],"familyNames":[{"familyName":"Uemura","familyNameLang":"en"}],"givenNames":[{"givenName":"Asumi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nadanaka,Satomi","creatorNameLang":"en","creatorNameType":"Personal"}],"familyNames":[{"familyName":"Nadanaka","familyNameLang":"en"}],"givenNames":[{"givenName":"Satomi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kitagawa,Hiroshi","creatorNameLang":"en","creatorNameType":"Personal"},{"creatorName":"キタガワ,ヒロシ","creatorNameLang":"ja-Kana","creatorNameType":"Personal"}],"familyNames":[{"familyName":"Kitagawa","familyNameLang":"en"},{"familyName":"キタガワ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Hiroshi","givenNameLang":"en"},{"givenName":"ヒロシ","givenNameLang":"ja-Kana"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"15101","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"鳥取大学","affiliationNameLang":"ja"},{"affiliationName":"Tottori University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"田村,純一","creatorNameLang":"ja","creatorNameType":"Personal"},{"creatorName":"Tamura,Jun-Ichi","creatorNameLang":"en","creatorNameType":"Personal"},{"creatorName":"タムラ,ジュンイチ","creatorNameLang":"ja-Kana","creatorNameType":"Personal"}],"familyNames":[{"familyName":"田村","familyNameLang":"ja"},{"familyName":"Tamura","familyNameLang":"en"},{"familyName":"タムラ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"純一","givenNameLang":"ja"},{"givenName":"Jun-Ichi","givenNameLang":"en"},{"givenName":"ジュンイチ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4859","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000039","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000039_ja.html"},{"nameIdentifier":"30221401","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30221401"}]}]},"item_30002_date11":{"attribute_name":"日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-02-10","subitem_date_issued_type":"Issued"}]},"item_30002_description9":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Chondroitin sulfate (CS), a linear acidic polysaccharide, exhibits numerous biological activities that are dependent on sulfation patterns. CS oligosaccharides comprise repeating disaccharide units with different (hetero)-type sulfation patterns and are common in nature. We herein report the synthesis of the following biotinylated CS tetrasaccharides: CS-AD [βGalNAc4S(1–4)βGlcA(1–3)βGalNAc6S(1–4)βGlcA2S] and CS-DA [βGalNAc6S(1–4)βGlcA2S(1–3)βGalNAc4S(1–4)βGlcA], in a stereo-controlled manner. We also demonstrated that the CS-d-specific monoclonal antibody MO-225 bound more strongly to CS-DA than to CS-DD or -AD.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_30002_file35":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-02-09"}],"displaytype":"detail","fileDate":[{"fileDateType":"Issued","fileDateValue":"2023-02-10"}],"filename":"bmc81_117191.pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","licensefree":"(C) 2023 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://repository.lib.tottori-u.ac.jp/record/2001705/files/bmc81_117191.pdf"},"version_id":"8761b270-702b-47cb-bde5-b19198ba8019"}]},"item_30002_language12":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30002_page_start27":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"117191"}]},"item_30002_publisher10":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier BV","subitem_publisher_language":"en"}]},"item_30002_relation18":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bmc.2023.117191","subitem_relation_type_select":"DOI"}}]},"item_30002_resource_type13":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_30002_rights6":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"(C) 2023 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_30002_source_identifier22":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"14643391","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"09680896","subitem_source_identifier_type":"PISSN"}]},"item_30002_source_title23":{"attribute_name":"収録物名","attribute_value_mlt":[{"subitem_source_title":"Bioorganic & medicinal chemistry","subitem_source_title_language":"en"}]},"item_30002_subject8":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"Chondroitin sulfate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Glycosylation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oligosaccharide synthesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mAb MO-225","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30002_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis of biotinylated chondroitin sulfate DA and AD tetrasaccharides composed of hetero-type disaccharide units, and their interactions with the mAb MO-225","subitem_title_language":"en"}]},"item_30002_version_type15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_30002_volume_number24":{"attribute_name":"巻","attribute_value_mlt":[{"subitem_volume":"81"}]},"item_title":"Synthesis of biotinylated chondroitin sulfate DA and AD tetrasaccharides composed of hetero-type disaccharide units, and their interactions with the mAb MO-225","item_type_id":"30002","owner":"10","path":["12","7"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-02-12"},"publish_date":"2025-02-12","publish_status":"0","recid":"2001705","relation_version_is_last":true,"title":["Synthesis of biotinylated chondroitin sulfate DA and AD tetrasaccharides composed of hetero-type disaccharide units, and their interactions with the mAb MO-225"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2025-02-13T08:37:58.612156+00:00"}