{"created":"2025-04-10T04:40:28.935249+00:00","id":2001799,"links":{},"metadata":{"_buckets":{"deposit":"54671b02-0e37-40f3-ba40-7e71eeb4a66e"},"_deposit":{"created_by":10,"id":"2001799","owner":"85","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2001799"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:02001799","sets":["1:9","2:12","23:34:1744609014513:1744609108080"]},"author_link":[],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2025-02-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicNumberOfPages":"10","bibliographicPageEnd":"21","bibliographicPageStart":"12","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: To evaluate and compare the survivals and radiotherapy-induced adverse events (AEs) of intensity-modulated radiotherapy (IMRT) with androgen deprivation therapy (ADT) and trimodality therapy, including low-dose iodine-125 brachytherapy, external beam radiotherapy, and ADT, for high-risk localized prostate cancer (LPC). Methods: High-risk patients with LPC at T stage ≥ 3a,Gleason score ≥ 8, and initial prostate-specific antigen ≥20.0 ng/mL treated between 2010 and 2021 were retrospectively evaluated. All the patients were treated with IMRT plus ADT or trimodality therapy. In both groups, ADT was initiated 6 months before and continued for 2 years after radiotherapy. Survival and acute and late radiation-induced AEs were evaluated and compared. Results: Two hundred and thirty-eight patients were treated with IMRT, and 91 underwent trimodality. Five-and 7-year biochemical-clinical failure-free survival (BCFFS) rates in the IMRT/trimodality group were 94.9/96.2, and 91.8/91.5%, respectively (P = 0.511). Stratified by 1–2/3 factors, 5- and 7-year BCFFS rates in the IMRT groups were 95.8/91.8, and 95.8/75.6%,respectively (P = 0.009). Five and 7-year BCFFS rates in the trimodality group were 96.8/94.1, and 91.4/94.1%, respectively (P = 0.995). The cumulative 3-/5-year incidence of late genitourinary AEs in the IMRT/trimodality group was 7.3/8.4, and 15.5/16.9%, respectively(P = 0.037), and the cumulative 3-/5-year incidence of late gastrointestinal AEs was 2.2/3.4, and 11.0/12.2%, respectively (P = 0.001). Thirty patients (9.1%) could not complete long-term ADT. Conclusion: Treatment results of both IMRT and trimodality were considered to be good, and our results also indicated that the long-term survival of unfavorable high-risk patients with LPC who had three risk factors was poor in the IMRT group. Further treatment experience of both modalities must be accumulated with more appropriate patient allocations.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Medical Press","subitem_publisher_language":"en"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"en","subitem_relation_name_text":"Yutaka Kitagawa, Kenji Yoshida, Yuuki Takeuchi, Tomohiko Tanino, Hiromi Sakaguchi, Ryutaro Shimizu, Noriya Yamaguchi, Shuichi Morizane, Atsushi Takenaka. Comparison of the Survivals and Adverse Events for Localized High-Risk Prostate  Cancer Treated with Intensity-Modulated Radiotherapy Plus Androgen Deprivation  and Trimodality Therapy, Including Low-Dose Iodine-125 Brachytherapy and  External Beam Radiotherapy Plus Androgen Deprivation. Yonago Acta Medica, 2025, 68(1), 12-21, doi: https://doi.org/10.33160/yam.2025.02.002"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.33160/yam.2025.02.002"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.33160/yam.2025.02.002","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam68-1/68-1contents.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam68-1/68-1contents.html","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2025 Tottori University Medical 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cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"trimodality","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comparison of the Survivals and Adverse Events for Localized High-Risk Prostate  Cancer Treated with Intensity-Modulated Radiotherapy Plus Androgen Deprivation  and Trimodality Therapy, Including Low-Dose Iodine-125 Brachytherapy and  External Beam Radiotherapy Plus Androgen Deprivation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparison of the Survivals and Adverse Events for Localized High-Risk Prostate  Cancer Treated with Intensity-Modulated Radiotherapy Plus Androgen Deprivation  and Trimodality Therapy, Including Low-Dose Iodine-125 Brachytherapy and  External Beam Radiotherapy Plus Androgen Deprivation","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1744609108080"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-02-21"},"publish_date":"2025-02-21","publish_status":"0","recid":"2001799","relation_version_is_last":true,"title":["Comparison of the Survivals and Adverse Events for Localized High-Risk Prostate  Cancer Treated with Intensity-Modulated Radiotherapy Plus Androgen Deprivation  and Trimodality Therapy, Including Low-Dose Iodine-125 Brachytherapy and  External Beam Radiotherapy Plus Androgen Deprivation"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2025-10-01T04:33:34.423419+00:00"}