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Selective PPARα Modulator (SPPARMα) in the Era of the MASLD Pandemic: Current Insights and Future Prospects
https://repository.lib.tottori-u.ac.jp/records/2001870
https://repository.lib.tottori-u.ac.jp/records/20018702ddb0ce2-d5e0-4be8-ad6d-25718d036735
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
yam68(2)_91.pdf (3 MB)
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(C) 2025 Tottori University Medical Press
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| Item type | デフォルトアイテムタイプ（フル）(1) | |||||||||
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| 公開日 | 2025-05-30 | |||||||||
| タイトル | ||||||||||
| タイトル | Selective PPARα Modulator (SPPARMα) in the Era of the MASLD Pandemic: Current Insights and Future Prospects | |||||||||
| 言語 | en | |||||||||
| 作成者 |
杉原,誉明
× 杉原,誉明
研究者総覧鳥取大学
100001245_ja.html
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| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | clinical outcomes | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | metabolic dysfunction-associated steatotic liver disease | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | pemafibrate | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | peroxisome proliferator-activated receptor α | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | selective PPARα modulator | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a significant global health concern, affecting approximately 30% of the population. In Japan, its prevalence is also rising rapidly and is expected to reach 50% by 2040. This situation can be described as a “MASLD pandemic”, emphasizing the urgent need for effective therapeutic interventions. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that play essential roles in lipid metabolism, inflammation regulation, and fibrosis modulation. Among them, PPARα is a key regulator of lipid homeostasis, primarily expressed in the liver and other metabolically active tissues. Its activation promotes fatty acid oxidation and improves lipid profiles, making it a crucial target for metabolic disorders. In Japan, a novel selective PPARα modulator (SPPARMα) was developed as a lipid-lowering agent for treating dyslipidemia. Over time, increasing clinical evidence has suggested that SPPARMα has beneficial effects on MASLD patients’ liver function. This review aims to summarize the therapeutic potential of SPPARMα in MASLD by examining the functional mechanisms of PPARα, preclinical studies in animal models, and accumulating clinical evidence from MASLD patients. Furthermore, we provide an overview of ongoing clinical trials investigating SPPARMα for MASLD treatment. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Tottori University Medical Press | |||||||||
| 言語 | en | |||||||||
| 日付 | ||||||||||
| 日付 | 2025-05-27 | |||||||||
| 日付タイプ | Issued | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 関連情報 | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.33160/yam.2025.05.002 | |||||||||
| 関連情報 | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://www.lib.tottori-u.ac.jp/yam/yam/yam68-2/68-2contents.html | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 05135710 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 13468049 | |||||||||
| 書誌情報 |
en : Yonago Acta Medica 巻 68, 号 2, p. 91-105, ページ数 15, 発行日 2025-05-27 |
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| 見出し | ||||||||||
| 大見出し | Review Article : Special Contribution | |||||||||
| 言語 | en | |||||||||
| 出版者情報 | ||||||||||
| 出版者名 | Tottori University Medical Press | |||||||||
| 言語 | en | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 権利情報 | ||||||||||
| 言語 | en | |||||||||
| 権利情報 | (C) 2025 Tottori University Medical Press | |||||||||
