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Associations Between Developmental Disorders, Early Seizure Onset, and Polytherapy in Childhood Epilepsy
https://repository.lib.tottori-u.ac.jp/records/2001873
https://repository.lib.tottori-u.ac.jp/records/20018738db5c845-359f-445c-b9eb-e01f9612716c
| 名前 / ファイル | ライセンス | アクション |
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yam68(2)_123.pdf (1.3 MB)
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(C) 2025 Tottori University Medical Press
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| Item type | デフォルトアイテムタイプ（フル）(1) | |||||||||||||||||
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| 公開日 | 2025-06-01 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Associations Between Developmental Disorders, Early Seizure Onset, and Polytherapy in Childhood Epilepsy | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 作成者 |
太田,健人
× 太田,健人
研究者総覧鳥取大学
100002580_ja.html
× 岡西,徹
研究者総覧鳥取大学
100002191_ja.html
× 前垣,義弘
研究者総覧鳥取大学
100000249_ja.html
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| 主題 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | attention-deficit/hyperactivity disorder | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | autism spectrum disorder | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | comorbidity | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | developmental disorder | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | epilepsy | |||||||||||||||||
| 内容記述 | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | Background : Epilepsy patients often exhibit symptoms of attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). This study aimed to compare the clinical characteristics of epilepsy in patients comorbid with ADHD/ASD and those diagnosed with ADHD/ASD after epilepsy onset. Methods : We retrospectively reviewed patients under 18 years of age with epilepsy who visited Tottori University Hospital’s Child Neurology Department during 2013–2022. Eligible patients had at least 2 years of follow-up after epilepsy onset and were taking antiseizure medication (ASM). We excluded those with epileptic encephalopathy, abnormal perinatal history, imaging abnormalities, or intellectual disabilities. We compared clinical characteristics between epilepsy patients with and without ADHD/ASD. Results : Data were collected from 28 patients with ADHD/ASD and 87 without. Patients with ADHD/ASD had an earlier seizure onset (6.6 ± 3.9 vs. 8.7 ± 4.1 years, P = 0.018) and were more likely to receive ASM polytherapy (39% vs. 16%, P = 0.010). Seizure outcomes did not differ between the two groups. Of the 28 patients with ADHD/ASD, 11 were diagnosed after epilepsy onset, and these patients were more likely to require multiple ASMs than those without ADHD/ASD(45% vs. 16%, P = 0.035). Conclusion : Patients comorbid with ADHD/ASD tend to have earlier seizure onset and require more ASM, while those diagnosed with ADHD/ASD after epilepsy onset also often need polytherapy. These findings suggest that severe early epilepsy can lead to developmental disorders, though long-term seizure outcomes are not necessarily poor in these patients. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Tottori University Medical Press | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 日付 | ||||||||||||||||||
| 日付 | 2025-05-27 | |||||||||||||||||
| 日付タイプ | Issued | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| 関連情報 | ||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | https://doi.org/10.33160/yam.2025.05.007 | |||||||||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||
| 関連識別子 | https://www.lib.tottori-u.ac.jp/yam/yam/yam68-2/68-2contents.html | |||||||||||||||||
| 収録物識別子 | ||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||
| 収録物識別子 | 05135710 | |||||||||||||||||
| 収録物識別子 | ||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||
| 収録物識別子 | 13468049 | |||||||||||||||||
| 書誌情報 |
en : Yonago Acta Medica 巻 68, 号 2, p. 123-130, ページ数 8, 発行日 2025-05-27 |
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| 見出し | ||||||||||||||||||
| 大見出し | Original Article | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 出版者情報 | ||||||||||||||||||
| 出版者名 | Tottori University Medical Press | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 権利情報 | (C) 2025 Tottori University Medical Press | |||||||||||||||||
