{"created":"2023-08-02T03:55:23.465738+00:00","id":4306,"links":{},"metadata":{"_buckets":{"deposit":"836ed86c-b273-492c-a799-d0e25a26deb3"},"_deposit":{"created_by":10,"id":"4306","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4306"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004306","sets":["1:9","2:14","23:40:797:798"]},"author_link":["2212","37547","37548","37549","37550","4746","2048","3118","37551","37552","377","37553","37554","37555","37556","37557","37558"],"item_3_alternative_title_31":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"イガン　フクスイチュウ　エクソソーム　ニ　ソンザイスル　microRNA　ノ　リンショウオウヨウ　ニ　ムケタ　キソテキケンキュウ","subitem_alternative_title_language":"ja-Kana"}]},"item_3_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-08-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-4","bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographicVolumeNumber":"72","bibliographic_titles":[{"bibliographic_title":"米子医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"The Journal of the Yonago Medical Association","bibliographic_titleLang":"en"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The purpose of this study is to explore the exosomal microRNAs obtained from peritoneal fluids of gastric cancer patients, which are specific for peritoneal metastasis （PM） and could be a predictive marker of disease status in PM. Exosomes were isolated from peritoneal fluids of patients of gastric cancer with PM. Presence of isolated extracellular vesicles （EVs） from peritoneal fluid specimens were confirmed using a transmission electron microscope showed that many EVs were approximately 100 nm in diameter, which were equivalent to exosome fractions. We carried out RNA extraction and comprehensive array analysis of exosomal microRNAs and have identified that 86 microRNAs were significantly up- or down-regulated in all 4 specimens and that out of them, miR-323-3p was highly expressed in all 4 cases. In this way, we have established an experimental system for measuring exosomal microRNAs in peritoneal lavage specimens. Next, we plan to apply this analysis for additional peritoneal lavage specimens obtained from gastric cancer patients with or without PM and to identify specific microRNAs, which could be predictive biomarkers for the disease status of PM in gastric cancer.","subitem_description_type":"Other"}]},"item_3_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"米子医学会"}]},"item_3_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"米子医学雑誌. 2021, 72(1-4), 1-5."}]}]},"item_3_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://mol.medicalonline.jp/library/journal/abstract?GoodsID=eb3yonai/2021/007201/001&name=0001-0005j"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://mol.medicalonline.jp/library/journal/abstract?GoodsID=eb3yonai/2021/007201/001&name=0001-0005j","subitem_relation_type_select":"URI"}}]},"item_3_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted."}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00247383","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00440558","subitem_source_identifier_type":"ISSN"}]},"item_3_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"鳥取大学医学部　器官制御外科学講座　消化器・小児外科学分野"},{"subitem_text_value":"鳥取大学技術部　化学バイオ・生命部門"},{"subitem_text_value":"鳥取大学医学部　器官制御外科学講座　消化器・小児外科学分野"},{"subitem_text_value":"鳥取大学医学部　器官制御外科学講座　消化器・小児外科学分野"},{"subitem_text_value":"鳥取大学医学部　器官制御外科学講座　消化器・小児外科学分野"},{"subitem_text_value":"鳥取大学医学部　器官制御外科学講座　消化器・小児外科学分野"},{"subitem_text_value":"鳥取大学医学部　器官制御外科学講座　消化器・小児外科学分野"},{"subitem_text_value":"鳥取大学医学部　器官制御外科学講座　消化器・小児外科学分野"},{"subitem_text_value":"鳥取大学医学部　器官制御外科学講座　消化器・小児外科学分野"},{"subitem_text_value":"鳥取大学医学部　電子顕微鏡室"},{"subitem_text_value":"鳥取大学医学部　器官制御外科学講座　消化器・小児外科学分野"}]},"item_3_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Chemical Biology, Technical Department, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, 　Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, 　Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, 　Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, 　Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, 　Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, 　Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, 　Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Laboratory of Electron Microscopy, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, 　Tottori University Faculty of Medicine"}]},"item_3_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宮谷, 幸造"},{"creatorName":"ミヤタニ, コウゾウ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyatani, Kozo","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"柗見, 吉朗"},{"creatorName":"マツミ, ヨシアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"澤田, 将平"},{"creatorName":"サワタ, ショウヘイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"牧野谷, 真弘"},{"creatorName":"マキノヤ, マサヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮内, 亘"},{"creatorName":"ミヤウチ, ワタル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宍戸, 裕二"},{"creatorName":"シシド, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Shishido, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"松永, 知之"},{"creatorName":"マツナガ, トモユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsunaga, Tomoyuki","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"坂本, 照尚"},{"creatorName":"サカモト, テルヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakamoto, Teruhisa","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"長谷川, 利路"},{"creatorName":"ハセガワ, トシミチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"堀江, 享史"},{"creatorName":"ホリエ, アツシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤原, 義之"},{"creatorName":"フジワラ, ヨシユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujiwara, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Matsumi, Yoshiaki","creatorNameLang":"en"},{"creatorName":"マツミ, ヨシアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sawata, Shohei","creatorNameLang":"en"},{"creatorName":"サワタ, ショウヘイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Makinoya, Masahiro","creatorNameLang":"en"},{"creatorName":"マキノヤ, マサヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyauchi, Wataru","creatorNameLang":"en"},{"creatorName":"ミヤウチ, ワタル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Toshimichi","creatorNameLang":"en"},{"creatorName":"ハセガワ, トシミチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Horie, Atsushi","creatorNameLang":"en"},{"creatorName":"ホリエ, アツシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-28"}],"displaytype":"detail","filename":"jyma72(1-4)_1.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensefree":"注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jyma72(1-4)_1.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/4306/files/jyma72(1-4)_1.pdf"},"version_id":"80e8eb60-6a68-4879-b013-a253dc259010"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Gastric cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"peritoneal metastasis","subitem_subject_scheme":"Other"},{"subitem_subject":"exosome","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"biomarker","subitem_subject_scheme":"Other"},{"subitem_subject":"Gastric cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"peritoneal metastasis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"exosome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"biomarker","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"胃癌腹水中エクソソームに存在するmicroRNAの 臨床応用に向けた基礎的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胃癌腹水中エクソソームに存在するmicroRNAの 臨床応用に向けた基礎的研究","subitem_title_language":"ja"},{"subitem_title":"Clinical application of exosomal microRNAs in peritoneal fluids of gastric cancer patients with peritoneal metastases","subitem_title_language":"en"}]},"item_type_id":"3","owner":"10","path":["9","14","798"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-04"},"publish_date":"2021-11-04","publish_status":"0","recid":"4306","relation_version_is_last":true,"title":["胃癌腹水中エクソソームに存在するmicroRNAの 臨床応用に向けた基礎的研究"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-27T00:58:32.523510+00:00"}