{"created":"2023-08-02T03:55:26.661878+00:00","id":4368,"links":{},"metadata":{"_buckets":{"deposit":"1e939611-d950-45c3-81f7-acf709202043"},"_deposit":{"created_by":10,"id":"4368","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4368"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004368","sets":["1:9","2:14","23:40:816:820"]},"author_link":["1772"],"item_3_alternative_title_31":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"センショクタイ コウガク ギジュツ オ モチイタ ガン ヨクセイ イデンシ ノ ドウテイ","subitem_alternative_title_language":"ja-Kana"}]},"item_3_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-11-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"120","bibliographicPageStart":"109","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"米子医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"The Journal of the Yonago Medical Association","bibliographic_titleLang":"en"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Many tumor suppressor genes are involved in the multistep process of neoplastic development. However, the signaling mechanism that underlies the development of tumors has not yet been completely elucidated. Therefore, Discovery of a novel tumor suppressor gene plays a crucial role in our understanding of the development and progression of malignant tumors. Chromosome engineering technique that base on Microcell-mediated chromosome transfer （MMCT），which can be generally used to the introduction of a single chromosome to a variety of tumor cells, is one of effective approach for mapping and identification of tumor suppressor genes. We have identified paired-like homeodomain 1（PITX1）gene as a novel telomerase negative regulatory factor that inhibit the expression of telomerase reverse transcriptase （TERT）using chromosome engineering technique. Here, we describe a unique strategy from mapping to identification of tumor suppressor gene by using MMCT approach.","subitem_description_type":"Other"}]},"item_3_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"米子医学会"}]},"item_3_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"米子医学雑誌. 2015, 66(6), 109-122"}]}]},"item_3_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted."}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00247383","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00440558","subitem_source_identifier_type":"ISSN"}]},"item_3_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"鳥取大学大学院医学系研究科 機能再生医科学専攻 生体機能医工学講座 遺伝子機能工学部門"}]},"item_3_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"久郷, 裕之"},{"creatorName":"クゴウ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kugoh, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-12-04"}],"displaytype":"detail","filename":"jyma66(6)_109.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensefree":"注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jyma66(6)_109.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/4368/files/jyma66(6)_109.pdf"},"version_id":"cf0797ea-0643-4364-b8e7-dbca2bfc6f24"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"MMCT","subitem_subject_scheme":"Other"},{"subitem_subject":"PITX1","subitem_subject_scheme":"Other"},{"subitem_subject":"Chromosomal engineering","subitem_subject_scheme":"Other"},{"subitem_subject":"Telomerase","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor suppressor gene","subitem_subject_scheme":"Other"},{"subitem_subject":"MMCT","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PITX1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chromosomal engineering","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Telomerase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor suppressor gene","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"染色体工学技術を用いたがん抑制遺伝子の同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"染色体工学技術を用いたがん抑制遺伝子の同定","subitem_title_language":"ja"},{"subitem_title":"Identification of a tumor suppressor gene using chromosome engineering","subitem_title_language":"en"}]},"item_type_id":"3","owner":"10","path":["9","14","820"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"4368","relation_version_is_last":true,"title":["染色体工学技術を用いたがん抑制遺伝子の同定"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-27T01:11:17.265176+00:00"}