{"created":"2023-08-02T03:55:28.953981+00:00","id":4408,"links":{},"metadata":{"_buckets":{"deposit":"37adf459-f2b1-414d-b621-238b11edeaeb"},"_deposit":{"created_by":10,"id":"4408","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4408"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004408","sets":["1:9","2:14","23:40:834:835"]},"author_link":["2090"],"item_3_alternative_title_31":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"コウジョウセン　シュヨウ　ソシキ　ニ　オケル　テンシャ　ヨクセイ　インシ　PLZF　ノ　ハツゲン　パターン　ニ　ツイテ　ノ　ケントウ","subitem_alternative_title_language":"ja-Kana"}]},"item_3_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"21","bibliographicPageStart":"15","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"米子医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"The Journal of the Yonago Medical Association","bibliographic_titleLang":"en"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PLZF (Promyelocytic Leukemia Zn Finger) is a transcriptional repressor which is originally isolated from a patient with promyelocytic leukemia. Moreover, PLZF affects the key element of cell cycle progression such as cyclin A. So far, the functional role of PLZF in thyroid cells remains unclear. In this study, we analyzed the expression profile of PLZF in thyroid neoplasms. We estimated PLZF expression in normal thyroid (n=6), multinodular goiter (n=4), follicular adenoma (n=3), follicular carcinoma (n=1), papillary carcinoma (n=18) and anaplastic carcinoma (n=3). PLZF expression was estimated by immunohistochemical staining and western blotting. In all of papillary carcinoma, PLZF is expressed in cytosol with high intensity. In contrast, in normal thyroid, follicular adenoma and follicular carcinoma, P LZF is localized in nucleus. We speculate that the intracellular translocation of PLZF reflects the differentiation between benign and malignancy. Although follicular carcinoma is malignant tissue, its PLZF expression pattern was same as benign thyroid tissues. Then differentiation of PLZF expression in follicular carcinoma from papillary carcinoma and anaplastic carcinoma is due to retaining follicular structure. We presume that PLZF expression in nucleus could be related to the maintenance of follicular structure.","subitem_description_type":"Other"}]},"item_3_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"米子医学会"}]},"item_3_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"米子医学雑誌. 2012, 63(1), 15-21"}]}]},"item_3_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted."}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00247383","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00440558","subitem_source_identifier_type":"ISSN"}]},"item_3_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"鳥取大学医学部統合内科医学講座病態情報内科学分野(主任山本一博教授)"}]},"item_3_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松澤, 和彦"},{"creatorName":"マツザワ, カズヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuzawa, Kazuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-02-10"}],"displaytype":"detail","filename":"jyma63(1)_15.pdf","filesize":[{"value":"775.6 kB"}],"format":"application/pdf","licensefree":"注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jyma63(1)_15.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/4408/files/jyma63(1)_15.pdf"},"version_id":"c8d4ed67-d1cf-437c-9a1b-19c289d78be6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"PLZF","subitem_subject_scheme":"Other"},{"subitem_subject":"thyroid neoplasm","subitem_subject_scheme":"Other"},{"subitem_subject":"tumorigenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"folliculogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"PLZF","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"thyroid neoplasm","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumorigenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"folliculogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"甲状腺腫蕩組織における転写抑制因子PLZFの発現パターンについての検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"甲状腺腫蕩組織における転写抑制因子PLZFの発現パターンについての検討","subitem_title_language":"ja"},{"subitem_title":"Transcriptional repressor PLZF is differentially expressed in thyroid neoplasm，reflecting the impairment of follicular formation","subitem_title_language":"en"}]},"item_type_id":"3","owner":"10","path":["9","14","835"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"4408","relation_version_is_last":true,"title":["甲状腺腫蕩組織における転写抑制因子PLZFの発現パターンについての検討"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-27T01:05:23.893079+00:00"}