{"created":"2023-08-02T03:55:40.805709+00:00","id":4609,"links":{},"metadata":{"_buckets":{"deposit":"ae571be3-8102-4621-97af-049fb56b925b"},"_deposit":{"created_by":10,"id":"4609","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4609"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004609","sets":["1:9","2:12","23:34:975:976"]},"author_link":["1855","4952","2075","2330","820","4074","4896","16497","16498","16499","16500"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-02-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"66","bibliographicPageStart":"56","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica"},{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Diffuse large B-cell lymphoma, not otherwise specified (DLBCL-NOS), is the most frequent type of lymphoid neoplasm. Methods: We investigated the relationships between clinical factors of DLBCL-NOS and MYC immunohistochemistry (IHC) staining. Results: A total of 110 patients diagnosed with DLBCL-NOS from 2012 to 2020 at Tottori University Hospital and treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) chemotherapy were included. IHC staining of MYC in formalin-fixed, paraffin-embedded tumor specimens was performed, and ROC-curve analysis revealed the cut-off value of the MYC positive rate as 55%. The 2-year overall survival (OS) rates of the MYC-negative and -positive groups were 84.7% vs 57.7% (P = 0.0091), and the progression-free survival rates were 77.8% vs 54.7% (P = 0.016), respectively. Multivariate analysis for OS showed prognostic significance of MYC positivity [hazards ratio (HR): 2.496; P = 0.032], and serum levels of soluble interleukin-2 receptor (sIL-2R) > 2000 U/mL (HR: 3.950; P = 0.0019), as well as age > 75 (HR: 2.356; P = 0.068). The original scoring system was developed based on these findings. By assigning one point to each item, age (> 75), MYC positivity, and sIL-2R level (> 2000), all patients were classified into three risk categories: group 1 (0 points), group 2 (1 point), and group 3 (2–3 points). The 2-year survival rates were 100%, 83.0%, and 47.1% for the groups 1, 2, and 3, respectively (P < 0.0001). Conclusion: We suggest that a prognostic scoring system using MYC expression and soluble interleukin receptor -2 level is useful for the prediction of prognosis, contributing to further stratification in DLBCL-NOS.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Medical Press"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.33160/yam.2023.02.007","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta Medica. 2023, 66(1), 56-66. doi:10.33160/yam.2023.02.007"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam66-1/66-1contents.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam66-1/66-1contents.html","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.33160/yam.2023.02.007"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.33160/yam.2023.02.007","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2023 Tottori University Medical Press."}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05135710","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"13468049"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Tottori University Hospital / Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pathology, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Tottori University Hospital / Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pathobiological Science and Technology, School of Health Science, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Tottori University Hospital / Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Tottori University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Tottori University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Tottori University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Pathology, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Tottori University Hospital"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"桑本, 聡史"},{"creatorName":"クワモト, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kuwamoto, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"河村, 浩二"},{"creatorName":"カワムラ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawamura, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"松下, 倫子"},{"creatorName":"マツシタ, ミチコ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsushita, Michiko","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"本倉, 徹"},{"creatorName":"モトクラ, トオル","creatorNameLang":"ja-Kana"},{"creatorName":"Motokura, Toru","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"細田, 譲"},{"creatorName":"ホソダ, ユズル","creatorNameLang":"ja-Kana"},{"creatorName":"Hosoda, Yuzuru","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"梅北, 善久"},{"creatorName":"ウメキタ, ヨシヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Umekita, Yoshihisa","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"福田, 哲也"},{"creatorName":"フクダ, テツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuda, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Suzuki, Sayaka","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maegaki, Masaya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hosoda, Rina","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Kentaro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-15"}],"displaytype":"detail","filename":"yam66(1)_56.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensefree":"(C) 2023 Tottori University Medical Press.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"yam66(1)_56.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/4609/files/yam66(1)_56.pdf"},"version_id":"cdf6d2de-40e5-42c6-9deb-4ad39ae1c004"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"diffuse large B-cell lymphoma","subitem_subject_scheme":"Other"},{"subitem_subject":"not otherwise specified","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"MYC","subitem_subject_scheme":"Other"},{"subitem_subject":"Proto-Oncogene Proteins","subitem_subject_scheme":"Other"},{"subitem_subject":"non-Hodgkin lymphoma","subitem_subject_scheme":"Other"},{"subitem_subject":"R-CHOP chemotherapy","subitem_subject_scheme":"Other"},{"subitem_subject":"diffuse large B-cell lymphoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"not otherwise specified","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MYC","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Proto-Oncogene Proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"non-Hodgkin lymphoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"R-CHOP chemotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Development of a Prognostic Scoring System using MYC Expression and Soluble Interleukin Receptor -2 level for Diffuse Large B-cell Lymphoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of a Prognostic Scoring System using MYC Expression and Soluble Interleukin Receptor -2 level for Diffuse Large B-cell Lymphoma","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","976"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-02-28"},"publish_date":"2023-02-28","publish_status":"0","recid":"4609","relation_version_is_last":true,"title":["Development of a Prognostic Scoring System using MYC Expression and Soluble Interleukin Receptor -2 level for Diffuse Large B-cell Lymphoma"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-28T23:45:52.518747+00:00"}