{"created":"2023-08-02T03:55:41.344488+00:00","id":4619,"links":{},"metadata":{"_buckets":{"deposit":"55b2e9a5-7a66-47a9-a5a7-fff1d197f191"},"_deposit":{"created_by":10,"id":"4619","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4619"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004619","sets":["1:9","2:12","23:34:975:976"]},"author_link":["16526","16527","1680","2777","16528","16529","16530","16531"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-02-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"158","bibliographicPageStart":"153","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica"},{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The use of stem/ progenitor cell-derived organoids to evaluate the toxicity of chemical substances has widely increased. Organoids with nephron-like structures (NLS) can be derived from rat adult kidney stem/ progenitor cells (rKS cells) using three-dimensional culture. In this study, we examined the effects of cisplatin, an anticancer drug that induces nephrotoxicity in vivo, on rKS cell-derived NLS. Methods: Twelve organoids were simultaneously derived from three-dimensionally cultured rKS cells in Matrigel matrices. The surface area of each organoid was measured using microscopy-based imaging, and the morphological changes of NLS were monitored using an image analysis method. NLS were exposed to cisplatin, and their associated effects were assessed. Results: NLS elongated over time. The surface areas of the 12 organoids were almost constant. Cisplatin exposure induced cell death in NLS and inhibited the increase in the surface area of the organoids. Conclusion: Cisplatin exposure induces damage to NLS derived from rKS cells. Thus, the organoids may be valuable as an in vitro model to assess nephrotoxicity.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Medical Press"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.33160/yam.2023.02.018","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta Medica. 2023, 66(1), 153-158. doi:10.33160/yam.2023.02.018"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam66-1/66-1contents.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam66-1/66-1contents.html","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.33160/yam.2023.02.018"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.33160/yam.2023.02.018","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2023 Tottori University Medical Press."}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05135710","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"13468049"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Research Facility, Advanced Medicine & Translational Research Center, Organization for Research Initiative and Promotion, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences"},{"subitem_text_language":"en","subitem_text_value":"Research Facility, Advanced Medicine & Translational Research Center, Organization for Research Initiative and Promotion, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Research Facility, Advanced Medicine & Translational Research Center, Organization for Research Initiative and Promotion, Tottori University / Research and Development Division, Kikkoman Corporation"},{"subitem_text_language":"en","subitem_text_value":"Department of Biomolecular Science, Faculty of Science, Toho University"},{"subitem_text_language":"en","subitem_text_value":"Research Facility, Advanced Medicine & Translational Research Center, Organization for Research Initiative and Promotion, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kuromi, Yasushi"},{"creatorName":"クロミ, ヤスシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Endo, Takeshi"},{"creatorName":"エンドウ, タケシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"古倉, 健嗣"},{"creatorName":"コクラ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kokura, Kenji","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"大林, 徹也"},{"creatorName":"オオバヤシ, テツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohbayashi, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kuromi, Yasushi","creatorNameLang":"en"},{"creatorName":"クロミ, ヤスシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitamura, Shinji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Endo, Takeshi","creatorNameLang":"en"},{"creatorName":"エンドウ, タケシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueno, Shota","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-15"}],"displaytype":"detail","filename":"yam66(1)_153.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensefree":"(C) 2023 Tottori University Medical Press.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"yam66(1)_153.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/4619/files/yam66(1)_153.pdf"},"version_id":"16490f51-47b9-4f4d-be98-a188fc4ebc8e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cell death","subitem_subject_scheme":"Other"},{"subitem_subject":"cisplatin","subitem_subject_scheme":"Other"},{"subitem_subject":"kidney organoids","subitem_subject_scheme":"Other"},{"subitem_subject":"stem cells","subitem_subject_scheme":"Other"},{"subitem_subject":"three-dimensional culture","subitem_subject_scheme":"Other"},{"subitem_subject":"cell death","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cisplatin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"kidney organoids","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stem cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"three-dimensional culture","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Cisplatin Induces Cell Death in Rat Adult Kidney Stem/ Progenitor Cell-Derived Kidney Organoids","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cisplatin Induces Cell Death in Rat Adult Kidney Stem/ Progenitor Cell-Derived Kidney Organoids","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","976"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-02-28"},"publish_date":"2023-02-28","publish_status":"0","recid":"4619","relation_version_is_last":true,"title":["Cisplatin Induces Cell Death in Rat Adult Kidney Stem/ Progenitor Cell-Derived Kidney Organoids"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-28T23:46:25.530436+00:00"}