{"created":"2023-08-02T03:55:41.477807+00:00","id":4621,"links":{},"metadata":{"_buckets":{"deposit":"4bdbbf82-91d5-40f7-b04b-ca37ba4b1e8d"},"_deposit":{"created_by":10,"id":"4621","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4621"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004621","sets":["1:9","2:12","23:34:975:976"]},"author_link":["16534","16535","16536","16537"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-02-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"179","bibliographicPageStart":"171","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica"},{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: There lacks a sufficient research on the tumorigenesis of clear cell renal cell carcinoma (ccRCC), causing that the prognosis of ccRCC was not effectively improved. Micall2 contributes to the malignancy of cancer. Moreover, Micall2 is considered a typical cell mobility-promoting factor. However, the relationship between Micall2 and ccRCC malignancy is unknown. Methods: In this study, we first investigated the expression patterns of Micall2 in ccRCC tissues and cell lines. Next, we explored the in vitro and in vivo roles of Micall2 in ccRCC tumorigenesis based on ccRCC cell lines with different Micall2 expression and gene manipulation assays. Results: Our study showed that ccRCC tissues and cell lines expressed higher level of Micall2 than paracancerous tissues and normal renal tubular epithelial cell, and Micall2 expression was overexpressed on cancerous tissue with significant metastasis and enlargement. Among three ccRCC cell lines, the expression of Micall2 was the highest in 786-O cells and the lowest in CAKI-1 cells. Moreover, 786-O cells showed the highest malignancy in vitro and in vivo (including proliferation, migration, invasion, reduced E-cadherin expression and tumorigenicity of nude mice in vivo), while CAKI-1 cells showed the contrary results. Furthermore, the upregulated Micall2 by Gene overexpression promoted the proliferation, migration and invasion of ccRCC cells while the downregulated Micall2 by Gene silencing showed the opposite effect. Conclusion: Micall2, as a pro-tumorigenic gene marker of ccRCC, contributes the malignancy of ccRCC.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Medical Press"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.33160/yam.2023.02.021","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta Medica. 2023, 66(1), 171-179. doi:10.33160/yam.2023.02.021"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam66-1/66-1contents.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam66-1/66-1contents.html","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.33160/yam.2023.02.021"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.33160/yam.2023.02.021","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2023 Tottori University Medical Press."}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05135710","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"13468049"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Urology, The Affiliated Hospital of Jinggangshan University"},{"subitem_text_language":"en","subitem_text_value":"Department of Urology, Chongqing Fengdu people’s Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Urology, Chongqing Fengdu people’s Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Stomatology, The Affiliated Hospital of Jinggangshan University"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zeng, Xianyou","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wang, Hongquan","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yang, Jia","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hu, Jing","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ccRCC","subitem_subject_scheme":"Other"},{"subitem_subject":"malignancy","subitem_subject_scheme":"Other"},{"subitem_subject":"Micall2","subitem_subject_scheme":"Other"},{"subitem_subject":"migration","subitem_subject_scheme":"Other"},{"subitem_subject":"mobility","subitem_subject_scheme":"Other"},{"subitem_subject":"ccRCC","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"malignancy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Micall2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"migration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mobility","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Micall2 Is Responsible for the Malignancy of Clear Cell Renal Cell Carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Micall2 Is Responsible for the Malignancy of Clear Cell Renal Cell Carcinoma","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","976"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-02-28"},"publish_date":"2023-02-28","publish_status":"0","recid":"4621","relation_version_is_last":true,"title":["Micall2 Is Responsible for the Malignancy of Clear Cell Renal Cell Carcinoma"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-28T23:46:30.493831+00:00"}