{"created":"2023-08-02T03:55:41.758958+00:00","id":4627,"links":{},"metadata":{"_buckets":{"deposit":"4a72f6c4-9497-45f2-b5ad-d5d5e06d7cd6"},"_deposit":{"created_by":10,"id":"4627","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4627"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004627","sets":["1:9","2:12","23:34:978:979"]},"author_link":["938","16550","16551","16552","16553","16554","16555"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-02-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"25","bibliographicPageStart":"14","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica"},{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Only a few studies have been reported on the use of dexmedetomidine for sedating surgical patients requiring epidural or spinal anesthesia. We conducted a randomized, double-blind, placebo-controlled, parallel-group study at 12 hospitals in Japan. Methods: Adult patients were randomly allocated to receive an intravenous administration of placebo or dexmedetomidine at 0.067, 0.25, 0.5 or 1.0 μg/kg over 10 min after epidural or spinal anesthesia. All dexmedetomidine groups received dexmedetomidine 0.2–0.7 μg/kg/h to maintain an Observer’s Assessment of Alertness/Sedation Scale (OAA/S) score of ≤ 4; however, propofol was administered to rescue patients who exceeded this score. Surgery was then started 15 min after study drug infusion in patients with OAA/S score of ≤ 4. The primary endpoint was the percentage of patients not requiring rescue propofol to achieve and maintain an OAA/S score of ≤ 4. Results: Of the 120 enrolled and randomized patients, 119 were treated the study: 22 received placebo and 97 received dexmedetomidine (23–25 patients per dose). Significantly more patients did not require propofol in the dexmedetomidine 0.5 and 1.0 μg/kg groups (68.0% and 80.0%, respectively) compared to the placebo group (22.7%) (P = 0.003 and P < 0.001, respectively). Common adverse events (AEs) were protocol-defined respiratory depression, bradycardia and hypotension. There was no significant difference in the incidence of AEs between the dexmedetomidine and the placebo groups. Conclusion: We concluded that loading doses of 0.5 and 1.0 μg/kg dexmedetomidine, followed by an infusion at a rate of 0.2–0.7 μg/kg/h, provide effective and well-tolerated sedation for surgical patients during epidural or spinal anesthesia. Clinical trials.gov identifier: NCT01438957","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Medical Press"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.33160/yam.2022.02.002","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta Medica. 2022, 65(1), 14-25. doi:10.33160/yam.2022.02.002"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam65-1/65-1contents.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam65-1/65-1contents.html","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.33160/yam.2022.02.002"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.33160/yam.2022.02.002","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2022 Tottori University Medical Press."}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05135710","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"13468049"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Anesthesiology and Critical Care Medicine, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anesthesiology, Sapporo Medical University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Anesthesiology, Nippon Medical School"},{"subitem_text_language":"en","subitem_text_value":"Clinical Statistics Group 2, Biometrics & Data Management, Pfizer R&D"},{"subitem_text_language":"en","subitem_text_value":"Clinical Development Department, Maruishi Pharmaceutical Co., Ltd."},{"subitem_text_language":"en","subitem_text_value":"Clinical Development Department, Maruishi Pharmaceutical Co., Ltd."},{"subitem_text_language":"en","subitem_text_value":"Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"稲垣, 喜三"},{"creatorName":"イナガキ, ヨシミ","creatorNameLang":"ja-Kana"},{"creatorName":"Inagaki, Yoshimi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"938","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40184717","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40184717"},{"nameIdentifier":"100000092","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000092_ja.html"}]},{"creatorNames":[{"creatorName":"Yamakage, Michiaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakamoto, Atsuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16551","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayama, Akifumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16552","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oya, Nobuyo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiraoka, Takehiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16554","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morita, Kiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16555","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-15"}],"displaytype":"detail","filename":"yam65(1)_14.pdf","filesize":[{"value":"840.3 kB"}],"format":"application/pdf","licensefree":"(C) 2022 Tottori University Medical Press.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"yam65(1)_14.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/4627/files/yam65(1)_14.pdf"},"version_id":"d7031858-6c9a-4805-b996-6cae10181dde"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"anesthesia","subitem_subject_scheme":"Other"},{"subitem_subject":"dexmedetomidine","subitem_subject_scheme":"Other"},{"subitem_subject":"epidural","subitem_subject_scheme":"Other"},{"subitem_subject":"propofol","subitem_subject_scheme":"Other"},{"subitem_subject":"spinal","subitem_subject_scheme":"Other"},{"subitem_subject":"anesthesia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dexmedetomidine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"epidural","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"propofol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"spinal","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Efficacy and Safety of Dexmedetomidine for Sedation During Surgery Under Epidural or Spinal Anesthesia: A Randomized, Double-Blind, Placebo-Controlled Study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Efficacy and Safety of Dexmedetomidine for Sedation During Surgery Under Epidural or Spinal Anesthesia: A Randomized, Double-Blind, Placebo-Controlled Study","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","979"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-09"},"publish_date":"2022-03-09","publish_status":"0","recid":"4627","relation_version_is_last":true,"title":["The Efficacy and Safety of Dexmedetomidine for Sedation During Surgery Under Epidural or Spinal Anesthesia: A Randomized, Double-Blind, Placebo-Controlled Study"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-28T23:46:50.564302+00:00"}