{"created":"2023-08-02T03:55:41.989927+00:00","id":4631,"links":{},"metadata":{"_buckets":{"deposit":"8de05fc4-7d75-4d59-bef9-89e2c957469f"},"_deposit":{"created_by":10,"id":"4631","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4631"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004631","sets":["1:9","2:12","23:34:978:979"]},"author_link":["2857","16567","16568","597","4358","16569","16570","16571","16572"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-02-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"69","bibliographicPageStart":"63","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica"},{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The BNT162b mRNA vaccine for coronavirus disease 2019, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mimics the immune response to natural infection. Few studies have predicted the adverse effects (AEs) after the second-dose vaccination. We present a predictive model for AEs and immune response after the second-dose of the BNT162b mRNA vaccine. Methods: To predict AEs, 282 healthcare workers (HCWs) were enrolled in this prospective observational study. The classification and regression tree (CART) model was established, and its predictive efficacy was assessed. To predict immune response, 282 HCWs were included in the analysis. Moreover, the factors affected by anti-SARS-CoV-2 spike protein RBD antibody (s-IgG) were evaluated using serum samples collected 2 months after the second-dose vaccination. The s-IgG level was assessed using Lumipulse G1200. Multiple regression analyses were conducted to evaluate variables associated with anti-s-IgG titer levels. Results: The most common AEs after the second-dose vaccination were pain (87.6%), redness (17.0%) at the injection site, fatigue (68.8%), headache (53.5%), and fever (37.5%). Based on the CART model, headache after the first-dose vaccination and age < 30 years were identified as the first and second discriminators for predicting the headache after the second-dose vaccination, respectively. In the multiple linear regression model, anti-s-IgG titer levels were associated with age, female sex, and AEs including headache and induration at the injection site after the second-dose vaccination. Conclusion: Headache after the first-dose vaccination can be a predictor of headache after the second-dose vaccination, and AEs are indicators of immune response.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Medical Press"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.33160/yam.2022.02.012","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta Medica. 2022, 65(1), 63-69. doi:10.33160/yam.2022.02.012"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam65-1/65-1contents.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam65-1/65-1contents.html","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.33160/yam.2022.02.012"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.33160/yam.2022.02.012","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2022 Tottori University Medical Press."}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05135710","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"13468049"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Pediatrics, National Hospital Organization Yonago Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Department of Respiratory Medicine, National Hospital Organization Yonago Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Department of Respiratory Medicine, National Hospital Organization Yonago Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Department of Respiratory Medicine, National Hospital Organization Yonago Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Department of Respiratory Medicine, National Hospital Organization Yonago Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Department of Internal Medicine, National Hospital Organization Yonago Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Division of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡田, 晋一"},{"creatorName":"オカダ, シンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Okada, Shinichi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Tomita, Katsuyuki"},{"creatorName":"トミタ, カツユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"唐下, 泰一"},{"creatorName":"トウゲ, ヒロカズ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"長谷川, 純一"},{"creatorName":"ハセガワ, ジュンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Hasegawa, Junichi","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"山崎, 章"},{"creatorName":"ヤマサキ, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamasaki, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Tomita, Katsuyuki","creatorNameLang":"en"},{"creatorName":"トミタ, カツユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inui, Genki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeuchi, Tomoyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Touge, Hirokazu","creatorNameLang":"en"},{"creatorName":"トウゲ, ヒロカズ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-15"}],"displaytype":"detail","filename":"yam65(1)_63.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensefree":"(C) 2022 Tottori University Medical Press.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"yam65(1)_63.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/4631/files/yam65(1)_63.pdf"},"version_id":"c401dad0-e35d-4972-b3f2-a659d9b5ba4c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adverse effect","subitem_subject_scheme":"Other"},{"subitem_subject":"antibody","subitem_subject_scheme":"Other"},{"subitem_subject":"BNT162b2 vaccine","subitem_subject_scheme":"Other"},{"subitem_subject":"classification and regression tree","subitem_subject_scheme":"Other"},{"subitem_subject":"adverse effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"BNT162b2 vaccine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"classification and regression tree","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Predictive Model for Adverse Events and Immune Response Based on the Production of Antibodies After the Second-Dose of the BNT162b2 mRNA Vaccine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Predictive Model for Adverse Events and Immune Response Based on the Production of Antibodies After the Second-Dose of the BNT162b2 mRNA Vaccine","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","979"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-09"},"publish_date":"2022-03-09","publish_status":"0","recid":"4631","relation_version_is_last":true,"title":["Predictive Model for Adverse Events and Immune Response Based on the Production of Antibodies After the Second-Dose of the BNT162b2 mRNA Vaccine"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-28T23:47:02.311328+00:00"}