@article{oai:repository.lib.tottori-u.ac.jp:00004633,
 author = {野坂, 加苗 and Nosaka, Kanae and 佐藤, 慎也 and Sato, Shinya and 大石, 徹郎 and Oishi, Tetsuro and 谷口, 文紀 and Taniguchi, Fuminori and 原田, 省 and Harada, Tasuku and Iida, Yuki and Komatsu, Hiroaki and Okawa, Masayo and Osaku, Daiken},
 issue = {1},
 journal = {Yonago Acta Medica, Yonago Acta Medica},
 month = {Feb},
 note = {Background: We investigated whether there was a difference in prognosis between patients with stage IA endometrial cancer with and without lymphovascular space invasion. Methods: We enrolled patients with stage IA (pT1aN0M0) endometrial cancer admitted to our hospital from 2009 to 2018. All patients underwent hysterectomy, bilateral salpingo-oophorectomy, and systematic pelvic lymphadenectomy. We immunopathologically evaluated the presence or absence of lymphovascular space invasion in the tumor tissue using hematoxylin and eosin, Elastica-van Gieson, and podoplanin staining. We analyzed disease-free and overall survival and calculated patients’ survival distribution using the Kaplan–Meier method and log-rank test. The multivariate analysis was performed to determine the prognostic factors. Results: A total of 116 patients were included. The median age of the patients was 57 (range, 30–78) years, and the histological subtype revealed 98 and 18 cases of types 1 and 2, respectively. The median follow-up period was 71.9 (range, 10.8–149) months, and the 3-year disease-free and 3-year overall survival rates were 94% and 99%, respectively. The disease-free and overall survival rates were significantly shorter in type 2 patients than in type 1 patients (type 2 vs. type 1; 77% vs. 97%, P < 0.01, 94% vs. 100%, P = 0.014, respectively). The univariate and multivariate analyses showed that there were no significant differences in disease-free survival between the lymphovascular space invasion-positive and -negative groups among type 1 cases. Conclusion: There was no difference in prognosis between patients with stage IA and type 1 endometrial cancer with and without lymphovascular space invasion.},
 pages = {82--87},
 title = {Is Adjuvant Chemotherapy Necessary in Patients with Early Endometrial Cancer?},
 volume = {65},
 year = {2022},
 yomi = {ノサカ, カナエ and サトウ, シンヤ and オオイシ, テツロウ and タニグチ, フミノリ and ハラダ, タスク}
}