@article{oai:repository.lib.tottori-u.ac.jp:00004641, author = {杉原, 誉明 and Sugihara, Takaaki and 永原, 天和 and Nagahara, Takakazu and 大山, 賢治 and Oyama, Kenji and 岡野, 淳一 and Okano, Jun-ichi and 桑本, 聡史 and Kuwamoto, Satoshi and 堀江, 靖 and Horie, Yasushi and 磯本, 一 and Isomoto, Hajime and Ikeda, Suguru and Kihara, Takuya and Hoshino, Yoshiki and Matsuki, Yukako}, issue = {2}, journal = {Yonago Acta Medica, Yonago Acta Medica}, month = {May}, note = {Chronic active Epstein–Barr virus (CAEBV) infection is a rare disease, mainly affecting children, typically characterized by persistent infectious mononucleosis (IM)-like symptoms. We describe an adult case of CAEBV without IM-like symptoms, which was indistinguishable from autoimmune hepatitis (AIH). A 60-year-old woman with liver damage was diagnosed with AIH (International Diagnostic Score: 16 points). She had been treated with prednisolone for three years; however, her transaminases had never normalized. She was admitted for another liver biopsy due to repeated high fevers and worsening of her liver damage over two months. Her EBV-DNA copy number was 2.9 × 104 copies/μg DNA, and EBV-encoded small RNA1-positive lymphocytic infiltration was observed in both the present and previously collected (three years ago) liver tissue samples. This case implies that hepatic involvement in a CAEBV without IM-like symptoms is difficult to distinguish from AIH and may be misdiagnosed. In some steroid resistant AIH cases, evaluating for CAEBV may be valuable.}, pages = {160--165}, title = {Chronic Active Epstein?Barr Virus Infection Indistinguishable from Autoimmune Hepatitis: A Case Report}, volume = {65}, year = {2022}, yomi = {スギハラ, タカアキ and ナガハラ, タカカズ and オヤマ, ケンジ and オカノ, ジュンイチ and クワモト, サトシ and ホリエ, ヤスシ and イソモト, ハジメ} }