@article{oai:repository.lib.tottori-u.ac.jp:00004671,
 author = {鞁嶋, 有紀 and Kawashima-Sonoyama, Yuki and 藤本, 正伸 and 三浦, 真澄 and Miura, Mazumi and 足立, 香織 and Adachi, Kaori and 難波, 栄二 and Nanba, Eiji and 難波, 範行 and Namba, Noriyuki and Narai, Satoshi and Fujimoto, Masanobu},
 issue = {1},
 journal = {Yonago Acta Medica, Yonago Acta Medica},
 month = {Feb},
 note = {[Background] Insulin and insulin-like growth factor (IGF) signaling plays an important role in prenatal and postnatal growth and glucose metabolism. Both small-for-gestational age (SGA) and preterm infants have abnormal growth and glucose metabolism. However, the underlying mechanism remains unknown. Recently, we showed that term SGA infants have abnormal insulin/IGF signaling in cord blood. In this study, we examined whether preterm infants show similar aberrations in cord blood insulin/IGF signaling. [Methods] A total of 41 preterm cord blood samples were collected. Blood glucose, insulin, IGF-1, and C-peptide concentrations were measured, and mRNA expression of IGF1R, INSR, IRS1, IRS2, and SLC2A4 (i.e., GLUT4) was analyzed by quantitative reverse-transcription PCR. [Results] This study included 34 appropriate-for-gestational age (AGA) and 7 SGA preterm neonates. No hyperinsulinemia or any differences in IGF1R or INSR mRNA expression were detected between the two groups. However, GLUT4 mRNA levels were increased in preterm SGA. Moreover, the expression level in hypoglycemic preterm SGA was significantly higher than that in hypoglycemic preterm AGA. IRS2 mRNA expression did not show a statistically significant difference between preterm SGA and AGA neonates. [Conclusion] SGA preterm birth does not induce hyperinsulinemia; however, it modifies insulin/IGF signaling components such as GLUT4 in umbilical cord blood. Our study suggests that prematurity or adaptation to malnutrition alters the insulin/IGF signaling pathway.},
 pages = {57--66},
 title = {Cord Blood from SGA Preterm Infants Exhibits Increased GLUT4 mRNA Expression},
 volume = {64},
 year = {2021},
 yomi = {カワシマ-ソノヤマ, ユキ and フジモト, マサノブ and ミウラ, マズミ and アダチ, カオリ and ナンバ, エイジ and ナンバ, ノリユキ and フジモト, マサノブ}
}