{"created":"2023-08-02T03:55:44.004731+00:00","id":4671,"links":{},"metadata":{"_buckets":{"deposit":"86082384-561f-4b89-8b86-05f0b28d9958"},"_deposit":{"created_by":10,"id":"4671","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4671"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004671","sets":["1:9","2:12","23:34:983:984"]},"author_link":["1455","16702","2173","28","2573","4943","16703","16704"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-02-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"66","bibliographicPageStart":"57","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica"},{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Background] Insulin and insulin-like growth factor (IGF) signaling plays an important role in prenatal and postnatal growth and glucose metabolism. Both small-for-gestational age (SGA) and preterm infants have abnormal growth and glucose metabolism. However, the underlying mechanism remains unknown. Recently, we showed that term SGA infants have abnormal insulin/IGF signaling in cord blood. In this study, we examined whether preterm infants show similar aberrations in cord blood insulin/IGF signaling. [Methods] A total of 41 preterm cord blood samples were collected. Blood glucose, insulin, IGF-1, and C-peptide concentrations were measured, and mRNA expression of IGF1R, INSR, IRS1, IRS2, and SLC2A4 (i.e., GLUT4) was analyzed by quantitative reverse-transcription PCR. [Results] This study included 34 appropriate-for-gestational age (AGA) and 7 SGA preterm neonates. No hyperinsulinemia or any differences in IGF1R or INSR mRNA expression were detected between the two groups. However, GLUT4 mRNA levels were increased in preterm SGA. Moreover, the expression level in hypoglycemic preterm SGA was significantly higher than that in hypoglycemic preterm AGA. IRS2 mRNA expression did not show a statistically significant difference between preterm SGA and AGA neonates. [Conclusion] SGA preterm birth does not induce hyperinsulinemia; however, it modifies insulin/IGF signaling components such as GLUT4 in umbilical cord blood. Our study suggests that prematurity or adaptation to malnutrition alters the insulin/IGF signaling pathway.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Medical Press"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.33160/yam.2021.02.009","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"S. Narai, Y. Kawashima-Sonoyama, M. Fujimoto, et al. Cord Blood from SGA Preterm Infants Exhibits Increased GLUT4 mRNA Expression. Yonago Acta Medica. 2021, 64(1), 57-66. doi:10.33160/yam.2021.02.009"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam64-1/64-1contents.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam64-1/64-1contents.html","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/article/yam/64/1/64_2021.02.009/_article/-char/ja"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/article/yam/64/1/64_2021.02.009/_article/-char/ja","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2021 Tottori University Medical Press"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05135710","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"13468049"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鞁嶋, 有紀"},{"creatorName":"カワシマ-ソノヤマ, ユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawashima-Sonoyama, Yuki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"藤本, 正伸"},{"creatorName":"フジモト, マサノブ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"三浦, 真澄"},{"creatorName":"ミウラ, マズミ","creatorNameLang":"ja-Kana"},{"creatorName":"Miura, Mazumi","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"足立, 香織"},{"creatorName":"アダチ, カオリ","creatorNameLang":"ja-Kana"},{"creatorName":"Adachi, Kaori","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"難波, 栄二"},{"creatorName":"ナンバ, エイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Nanba, Eiji","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"難波, 範行"},{"creatorName":"ナンバ, ノリユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Namba, Noriyuki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Narai, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimoto, Masanobu","creatorNameLang":"en"},{"creatorName":"フジモト, マサノブ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-15"}],"displaytype":"detail","filename":"yam64(1)_057.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensefree":"(C) 2021 Tottori University Medical 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age","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Cord Blood from SGA Preterm Infants Exhibits Increased GLUT4 mRNA Expression","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cord Blood from SGA Preterm Infants Exhibits Increased GLUT4 mRNA Expression","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","984"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-17"},"publish_date":"2021-03-17","publish_status":"0","recid":"4671","relation_version_is_last":true,"title":["Cord Blood from SGA Preterm Infants Exhibits Increased GLUT4 mRNA Expression"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-28T23:49:14.425838+00:00"}