@article{oai:repository.lib.tottori-u.ac.jp:00004677, author = {池淵, 雄一郎 and 菓, 裕貴 and 河口, 剛一郎 and Kawaguchi, Koichiro and 八島, 一夫 and Yashima, Kazuo and 磯本, 一 and Isomoto, Hajime and Ikebuchi, Yuichiro and Yoshida, Akira and Kurumi, Hiroki and Kamitani, Yu and Yasui, Sho and Nakada, Yusuke}, issue = {1}, journal = {Yonago Acta Medica, Yonago Acta Medica}, month = {Feb}, note = {[Background] Talaporfin sodium photodynamic therapy (TS-PDT) for local failure after chemoradiotherapy (CRT) in patients with esophageal squamous cell carcinoma has recently been reported to be highly effective and less invasive, compared to other treatment modalities. TS-PDT was recently introduced at the Tottori University Hospital, Japan. The aim of this study is to clarify the efficacy and safety of PDT in our hospital. [Methods] This was a single-center observational study. We examined eight cases of TS-PDT performed between January 2016 and December 2019. The main endpoints were local complete remission (L-CR) rate and the adverse events. In addition, age, gender, histology, tumor location, TNM stage, tumor depth, irradiation dose, and overall survival (OS) were examined. [Results] The patients included 7 men and a woman, with an average age of 72.1 years (range 63–82 years). The baseline clinical stages before CRT or radiotherapy were stage I in 1, stage II in 3, stage III in 3, and stage IVA in 1 patient. The T stage on endoscopic assessment before TS-PDT was T1 in 6 patients and T2 in 2 patients. Treatment outcomes and adverse events were evaluated. There were no treatment-related deaths, and no significant adverse events occurred intraoperatively or postoperatively. The L-CR rate was 7/8 (87.5%); T1 cases had 100% (6/6) L-CR, while T2 cases had 50% (1/2). The 2-year OS rates were 87%. [Conclusion] TS-PDT was observed to be safe and effective in the first eight cases of its application following its introduction in our hospital.}, pages = {120--125}, title = {Salvage Photodynamic Therapy Using Talaporfin Sodium for Local Failure of Esophageal Squamous Cell Carcinoma}, volume = {64}, year = {2021}, yomi = {イケブチ, ユウイチロウ and ヨシダ, アキラ and クルミ, ヒロキ and カワグチ, コウイチロウ and ヤシマ, カズオ and イソモト, ハジメ and イケブチ, ユウイチロウ and ヨシダ, アキラ and クルミ, ヒロキ} }