@article{oai:repository.lib.tottori-u.ac.jp:00004686, author = {徳安, 成郎 and Tokuyasu, Naruo and 網崎, 正孝 and Amisaki, Masataka and 花木, 武彦 and 村上, 裕樹 and Murakami, Yuki and 森本, 昌樹 and Morimoto, Masaki and Yagyu, Takuki and Goto, Keisuke and 松永, 知之 and Matsunaga, Tomoyuki and 山本, 学 and Yamamoto, Manabu and 高野, 周一 and Takano, Shuichi and 坂本, 照尚 and Sakamoto, Teruhisa and 本城, 総一郎 and Honjo, Soichiro and 藤原, 義之 and Fujiwara, Yoshiyuki and Hanaki, Takehiko and Uchinaka, Ei and Yagyu, Takuki and Goto, Keisuke and Hasegawa, Toshimichi}, issue = {2}, journal = {Yonago Acta Medica, Yonago Acta Medica}, month = {May}, note = {[Background] As antithrombin III (AT-III) is produced in the hepatocytes, its serum activity decreases at the time of liver failure, in addition to ischemia reperfusion injury, vascular endothelial dysfunction, and disseminated intravascular coagulation (DIC). Here, we examined whether the serum AT-III value after hepatectomy could be a prognostic factor for hepatocellular carcinoma (HCC). [Methods] Of 141 patients who underwent hepatectomy for HCC, data for 101 patients in whom serum AT-III activity was measured on the first postoperative day were extracted. Patients with serum AT-III activity > 50% and ? 50% were assigned to high value (72 cases) and low value (29 cases) groups, respectively. We examined the clinical and prognostic differences between these two groups. [Results] The average age of enrolled patients (83 men and 18 women) was 68.0 years. The 5-year overall survival rate was 88% and 60% in the high and low value groups, respectively (P < 0.01). Furthermore, the 2-year relapse-free survival rate was 71% and 54% in the high and low value groups, respectively (P = 0.03). [Conclusion] This is the first study to demonstrate that serum AT-III levels on the first postoperative day may serve as a prognostic factor in HCC patients.}, pages = {168--175}, title = {Clinical Significance of Serum Antithrombin III Activity After Hepatectomy for Hepatocellular Carcinoma}, volume = {64}, year = {2021}, yomi = {トクヤス, ナルオ and アミサキ, マサタカ and ハナキ, タケヒコ and ムラカミ, ユウキ and モリモト, マサキ and ヤギュウ, タクキ and ゴトウ, ケイスケ and マツナガ, トモユキ and ヤマモト, マナブ and タカノ, シュウイチ and サカモト, テルヒサ and ホンジョウ, ソウイチロウ and フジワラ, ヨシユキ and ハナキ, タケヒコ and ヤギュウ, タクキ and ゴトウ, ケイスケ} }